PMID- 8118480
OWN - NLM
STAT- MEDLINE
DCOM- 19940405
LR  - 20131121
IS  - 1230-6002 (Print)
IS  - 1230-6002 (Linking)
VI  - 45
IP  - 4
DP  - 1993 Jul-Aug
TI  - Ketamine, but not glycine modulates quinolinate-induced neurodegeneration.
PG  - 339-47
AB  - The influence of ketamine and glycine on the neurotoxicity of the 
      N-methyl-D-aspartate-(NMDA)-receptor agonist quinolinic acid [QUIN; injected 
      intracerebroventricularly (icv)] was studied in rats. Ketamine, an NMDA-receptor 
      antagonist prevented completely the QUIN-induced hippocampal damage at a dosage 
      of 40 mg/kg (140 mumol/kg, intraperitoneally applied). Glycine, a physiological 
      co-agonist of the NMDA-receptor, was applied icv in addition to QUIN. Even at 
      high doses (up to 1.33 mumol) glycine did not show any effects on QUIN 
      neurotoxicity, if the neurotoxin was administered at a subliminal dose (0.25 
      mumol). The apparent lack of a potentiating effect of exogenously applied glycine 
      favors the assumption that glycine binding sites are saturated under 
      physiological conditions.
FAU - Henschke, G
AU  - Henschke G
AD  - Institute of Medical Neurobiology, University of Magdeburg, Germany.
FAU - Wolf, G
AU  - Wolf G
FAU - Keilhoff, G
AU  - Keilhoff G
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Poland
TA  - Pol J Pharmacol
JT  - Polish journal of pharmacology
JID - 9313882
RN  - 690G0D6V8H (Ketamine)
RN  - F6F0HK1URN (Quinolinic Acid)
RN  - TE7660XO1C (Glycine)
SB  - IM
MH  - Animals
MH  - Behavior, Animal/drug effects
MH  - Glycine/administration & dosage/*pharmacology
MH  - Hippocampus/cytology/*drug effects/pathology
MH  - Injections, Intraperitoneal
MH  - Injections, Intraventricular
MH  - Ketamine/administration & dosage/*pharmacology
MH  - Male
MH  - Nerve Degeneration/*drug effects
MH  - Pyramidal Cells/*drug effects/pathology
MH  - Quinolinic Acid/administration & dosage/*toxicity
MH  - Rats
MH  - Rats, Wistar
EDAT- 1993/07/01 00:00
MHDA- 1993/07/01 00:01
CRDT- 1993/07/01 00:00
PHST- 1993/07/01 00:00 [pubmed]
PHST- 1993/07/01 00:01 [medline]
PHST- 1993/07/01 00:00 [entrez]
PST - ppublish
SO  - Pol J Pharmacol. 1993 Jul-Aug;45(4):339-47.