PMID- 8120136
OWN - NLM
STAT- MEDLINE
DCOM- 19940401
LR  - 20190825
IS  - 0165-5728 (Print)
IS  - 0165-5728 (Linking)
VI  - 50
IP  - 2
DP  - 1994 Mar
TI  - Induction of communicating hydrocephalus in mice by intrathecal injection of 
      human recombinant transforming growth factor-beta 1.
PG  - 153-8
AB  - Transforming growth factor-beta 1 (TGF-beta 1) is a multi-functional polypeptide, 
      which controls proliferation, differentiation of various cells, and regulates 
      synthesis of extracellular matrix proteins. We injected human recombinant 
      TGF-beta 1 into the subarachnoid space of 10-day-old C57BL/6 mice in order to 
      study the role of TGF-beta 1, which is known to be released from platelets into 
      the cerebrospinal fluid following subarachnoid hemorrhage. The ventricular system 
      became dilated within 3 weeks following the injection and the body weights of 
      injected mice stopped increasing 6 weeks after injection of TGF-beta 1. 
      Microscopic examination revealed dilatation of the ventricular system, and that 
      the outlets of the ventricles were not obliterated. Electron microscopy showed 
      diminution of cilia on the ependyma. These results demonstrate that TGF-beta 1 
      induces communicating hydrocephalus in mice. This hydrocephalic model should be 
      useful in further studies on the pathogenesis of normal pressure hydrocephalus 
      following subarachnoid hemorrhage in man.
FAU - Tada, T
AU  - Tada T
AD  - Department of Neurosurgery, Shinshu University School of Medicine, Matsumoto, 
      Japan.
FAU - Kanaji, M
AU  - Kanaji M
FAU - Kobayashi, S
AU  - Kobayashi S
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - J Neuroimmunol
JT  - Journal of neuroimmunology
JID - 8109498
RN  - 0 (Recombinant Proteins)
RN  - 0 (Transforming Growth Factor beta)
SB  - IM
MH  - Animals
MH  - Cerebral Ventricles/drug effects/pathology
MH  - Dilatation
MH  - Humans
MH  - Hydrocephalus/*chemically induced/pathology
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Microscopy, Electron, Scanning
MH  - Recombinant Proteins
MH  - *Transforming Growth Factor beta/pharmacology
EDAT- 1994/03/01 00:00
MHDA- 2000/06/01 09:00
CRDT- 1994/03/01 00:00
PHST- 1994/03/01 00:00 [pubmed]
PHST- 2000/06/01 09:00 [medline]
PHST- 1994/03/01 00:00 [entrez]
AID - 0165-5728(94)90041-8 [pii]
AID - 10.1016/0165-5728(94)90041-8 [doi]
PST - ppublish
SO  - J Neuroimmunol. 1994 Mar;50(2):153-8. doi: 10.1016/0165-5728(94)90041-8.