PMID- 8122120
OWN - NLM
STAT- MEDLINE
DCOM- 19940405
LR  - 20191023
IS  - 0049-0172 (Print)
IS  - 0049-0172 (Linking)
VI  - 23
IP  - 3
DP  - 1993 Dec
TI  - Late-onset, seropositive, erosive rheumatoid arthritis.
PG  - 177-82
AB  - This report describes the natural history, clinical features, and therapeutic 
      requirements of late-onset seropositive and/or erosive rheumatoid arthritis 
      (LORA). One hundred twenty-nine patients with mean disease duration of 6 years 
      and mean age of disease onset of 66 years were studied. All patients met American 
      Rheumatism Association criteria for rheumatoid arthritis (RA). Ninety-one percent 
      were seropositive for rheumatoid factor, 83% had erosive disease, and 58% had 
      significant medical problems. Therapeutically, most patients required sequential 
      use of multiple second-line agents. Functional classification did not change 
      significantly despite treatment, and complete remissions were unusual even with 
      remittive therapy. It is concluded that a subset of LORA patients have 
      seropositive aggressive, destructive disease.
FAU - Lance, N J
AU  - Lance NJ
AD  - Department of Medicine, Rush-Presbyterian-St Luke's Medical Center, Chicago, IL.
FAU - Curran, J J
AU  - Curran JJ
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Semin Arthritis Rheum
JT  - Seminars in arthritis and rheumatism
JID - 1306053
RN  - 0 (Anti-Inflammatory Agents, Non-Steroidal)
RN  - YL5FZ2Y5U1 (Methotrexate)
SB  - IM
MH  - Aged
MH  - Anti-Inflammatory Agents, Non-Steroidal/therapeutic use
MH  - Cohort Studies
MH  - Female
MH  - Humans
MH  - Male
MH  - Methotrexate/therapeutic use
MH  - Middle Aged
MH  - Radiography
MH  - Retrospective Studies
MH  - *Still's Disease, Adult-Onset/complications/diagnostic imaging/drug therapy
EDAT- 1993/12/01 00:00
MHDA- 1993/12/01 00:01
CRDT- 1993/12/01 00:00
PHST- 1993/12/01 00:00 [pubmed]
PHST- 1993/12/01 00:01 [medline]
PHST- 1993/12/01 00:00 [entrez]
AID - S0049-0172(05)80038-1 [pii]
AID - 10.1016/s0049-0172(05)80038-1 [doi]
PST - ppublish
SO  - Semin Arthritis Rheum. 1993 Dec;23(3):177-82. doi: 10.1016/s0049-0172(05)80038-1.