PMID- 8126032
OWN - NLM
STAT- MEDLINE
DCOM- 19940412
LR  - 20071114
IS  - 0021-9304 (Print)
IS  - 0021-9304 (Linking)
VI  - 28
IP  - 1
DP  - 1994 Jan
TI  - Theoretical analysis of in vivo macrophage adhesion and foreign body giant cell 
      formation on polydimethylsiloxane, low density polyethylene, and 
      polyetherurethanes.
PG  - 73-9
AB  - Quantitative description of foreign body giant cell (FBGC) formation on implanted 
      polymer surfaces as a function of time can conceivably correlate cell adhesion 
      with polymer properties and possibly predict the behavior of the polymer in vivo. 
      In the present study, the formation of FBGCs on various biomedical polymers was 
      quantified by two parameters: the density of adherent macrophages present 
      initially that participate in FBGC formation (d0) and the rate constant for cell 
      fusion (k); both kinetic parameters were used to calculate the time-dependent 
      FBGC density (dfc). The materials used were: three Pellethane 
      poly(etherurethanes) (PEUs) varying in weight percent of hard segment, one 
      poly(etherurethane urea) (PEUU), and NHLBI-DTB primary reference materials: low 
      density polyethylene (LDPE), silica-free polydimethylsiloxane (PDMS). The results 
      indicated that up to 5 weeks of implantation, FBGCs were formed from the fusion 
      of one population of adherent macrophages present by 3 days post-implantation. 
      Furthermore, only a small fraction (< 8%) of this initial adherent macrophage 
      population participated in FBGC formation. Based on the results of previous 
      studies and the current study, it was concluded that increase in PEU hard segment 
      weight percent, surface hardness and hydrophobicity increased total protein 
      adsorption and effectively increased d0 and dfc. No further correlations between 
      the material properties of all polymers and the cell kinetics can be made at this 
      time. However, this study demonstrated that macrophage adhesion and FBGC 
      formation can be quantified with the cell fusion model, and are modulated by 
      various polymer properties.
FAU - Kao, W J
AU  - Kao WJ
AD  - Department of Macromolecular Science, Case Western Reserve University, Cleveland, 
      Ohio 44106-4907.
FAU - Zhao, Q H
AU  - Zhao QH
FAU - Hiltner, A
AU  - Hiltner A
FAU - Anderson, J M
AU  - Anderson JM
LA  - eng
GR  - HL-25239/HL/NHLBI NIH HHS/United States
GR  - HL-33849/HL/NHLBI NIH HHS/United States
GR  - HL-47300/HL/NHLBI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - J Biomed Mater Res
JT  - Journal of biomedical materials research
JID - 0112726
RN  - 0 (Biocompatible Materials)
RN  - 0 (Dimethylpolysiloxanes)
RN  - 0 (Polyethylenes)
RN  - 0 (Polyurethanes)
RN  - 0 (Proteins)
RN  - 0 (polyetherurethane)
SB  - IM
EIN - J Biomed Mater Res 1994 Jun;28(6):761
MH  - Adsorption
MH  - Animals
MH  - *Biocompatible Materials/chemistry
MH  - Cell Adhesion/physiology
MH  - Cell Fusion
MH  - Dimethylpolysiloxanes/chemistry
MH  - Female
MH  - Foreign-Body Reaction/*immunology/pathology
MH  - *Giant Cells, Foreign-Body
MH  - Kinetics
MH  - Macrophages/*physiology
MH  - Models, Biological
MH  - Polyethylenes/chemistry
MH  - Polyurethanes/chemistry
MH  - Prostheses and Implants
MH  - Proteins/chemistry
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Surface Properties
EDAT- 1994/01/01 00:00
MHDA- 1994/01/01 00:01
CRDT- 1994/01/01 00:00
PHST- 1994/01/01 00:00 [pubmed]
PHST- 1994/01/01 00:01 [medline]
PHST- 1994/01/01 00:00 [entrez]
AID - 10.1002/jbm.820280110 [doi]
PST - ppublish
SO  - J Biomed Mater Res. 1994 Jan;28(1):73-9. doi: 10.1002/jbm.820280110.