PMID- 8129850
OWN - NLM
STAT- MEDLINE
DCOM- 19940415
LR  - 20190920
IS  - 1046-7408 (Print)
IS  - 1046-7408 (Linking)
VI  - 30
IP  - 4
DP  - 1993 Dec
TI  - Association between maternal-fetal HLA-DR relationships and fetal growth.
PG  - 246-53
AB  - PROBLEM: To determine whether maternal-fetal human leukocyte antigen (HLA) 
      antigenic relationships are associated with differential fetal growth in weight. 
      METHOD: A cohort of 659 primigravid women were enrolled in this study in the 
      prepartum period and their neonates were subsequently examined. Anthropometric, 
      maternal cigarette smoking behavior, health, pregnancy, and delivery data were 
      collected; serogenetic typing was conducted on maternal and cord bloods to 
      determine maternal and neonatal HLA antigenic phenotypes. Women and their 
      neonates were assigned to one of the four different types of maternal-fetal 
      relationships existing at each of the HLA-A, B, DR, and DQ loci. Birthweights 
      were treated quantitatively and qualitatively (neonates classified as 
      growth-retarded or normal). RESULTS: After controlling for other factors 
      influencing birthweight (e.g., smoking, maternal body size), significantly lower 
      birthweight trends (P < .01) were found when neonates expressed a single HLA-DR 
      antigen and their mothers expressed a second HLA-DR antigen that was foreign 
      (allogeneic) to their neonate. CONCLUSION: Our findings supports the hypothesis 
      that lack of maternal immune exposure to fetal HLA antigens is associated with a 
      slowing of fetal growth. However, in this situation slowed fetal growth is most 
      likely to occur when the fetus is potentially exposed to maternal HLA-DR 
      alloantigens. We believe this sheds new light on immunologic events at the 
      maternal-fetal interface influencing fetal growth. We present one possible 
      explanation to account for this finding.
FAU - Hoff, C
AU  - Hoff C
AD  - Department of Pediatrics, College of Medicine, University of South Alabama, 
      Mobile.
FAU - Peevy, K J
AU  - Peevy KJ
FAU - Spinnato, J A
AU  - Spinnato JA
FAU - Giattina, K
AU  - Giattina K
FAU - Peterson, R D
AU  - Peterson RD
LA  - eng
GR  - HD 21144/HD/NICHD NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - Denmark
TA  - Am J Reprod Immunol
JT  - American journal of reproductive immunology (New York, N.Y. : 1989)
JID - 8912860
RN  - 0 (HLA-DR Antigens)
SB  - IM
MH  - Birth Weight
MH  - Embryonic and Fetal Development/*immunology
MH  - Female
MH  - Fetal Growth Retardation/immunology
MH  - *HLA-DR Antigens
MH  - Humans
MH  - Immunization
MH  - Infant, Newborn
MH  - Maternal-Fetal Exchange/*immunology
MH  - Models, Biological
MH  - Phenotype
MH  - Pregnancy
MH  - Risk Factors
EDAT- 1993/12/01 00:00
MHDA- 1993/12/01 00:01
CRDT- 1993/12/01 00:00
PHST- 1993/12/01 00:00 [pubmed]
PHST- 1993/12/01 00:01 [medline]
PHST- 1993/12/01 00:00 [entrez]
AID - 10.1111/j.1600-0897.1993.tb00626.x [doi]
PST - ppublish
SO  - Am J Reprod Immunol. 1993 Dec;30(4):246-53. doi: 
      10.1111/j.1600-0897.1993.tb00626.x.