PMID- 8134111
OWN - NLM
STAT- MEDLINE
DCOM- 19940421
LR  - 20131121
IS  - 0950-9232 (Print)
IS  - 0950-9232 (Linking)
VI  - 9
IP  - 4
DP  - 1994 Apr
TI  - Unliganded c-erbA/thyroid hormone receptor induces trkB expression in 
      neuroblastoma cells.
PG  - 1081-9
AB  - Neurotrophins are responsible for the differentiation and survival of neurons in 
      the developing and in the adult nervous system. They bind to specific membrane 
      receptors with tyrosine kinase activity whose prototype is the product of the 
      trkA proto-oncogene. TrkB, a member of this family, is the receptor for the 
      neurotrophins brain derived growth factor (BDNF) and neurotrophins-3, -4/5. In 
      this study, we show that stable expression of the c-erbA proto-oncogene, which 
      encodes the alpha 1-isoform of the nuclear receptor for thyroid hormone (Tr alpha 
      1) induces the expression of trkB mRNA with a concomitant decrease to 
      undetectable levels of trkA and trkC mRNAs in the mouse neuroblastoma N2a cell 
      line. trkB induction by c-erbA is ligand independent, since addition of T3 had no 
      effect. The induced trkB transcript encodes a functional gp145trkB protein, which 
      is phosphorylated on tyrosine in response to BDNF. Furthermore, induction of trkB 
      mRNA is also caused by transient expression of either TR alpha 1 or beta 1 
      isoforms. Our results are compatible with the idea that there are certain 
      pathways which are under control of unliganded thyroid hormone receptor, and that 
      one of these pathways results in regulation of trk expression.
FAU - Pastor, R
AU  - Pastor R
AD  - Instituto Investigaciones Biomedicas, (CSIC), Facultad de Medicina, Universidad 
      Autonoma de Madrid, Spain.
FAU - Bernal, J
AU  - Bernal J
FAU - Rodriguez-Pena, A
AU  - Rodriguez-Pena A
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Oncogene
JT  - Oncogene
JID - 8711562
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Nerve Tissue Proteins)
RN  - 0 (Proto-Oncogene Proteins)
RN  - 0 (RNA, Messenger)
RN  - 0 (Receptors, Growth Factor)
RN  - 0 (Receptors, Nerve Growth Factor)
RN  - 0 (Receptors, Thyroid Hormone)
RN  - 0 (Thyroid Hormones)
RN  - 0 (brain-derived growth factor)
RN  - 1F7A44V6OU (Colforsin)
RN  - 5688UTC01R (Tretinoin)
RN  - EC 2.7.10.1 (Receptor Protein-Tyrosine Kinases)
RN  - EC 2.7.10.1 (Receptor, trkA)
RN  - EC 2.7.10.1 (Receptor, trkB)
RN  - EC 2.7.10.1 (Receptor, trkC)
SB  - IM
MH  - Animals
MH  - *Brain-Derived Neurotrophic Factor
MH  - Cell Differentiation/drug effects
MH  - Colforsin/pharmacology
MH  - Gene Expression Regulation, Neoplastic
MH  - Mice
MH  - Nerve Tissue Proteins/pharmacology
MH  - Neuroblastoma/*genetics
MH  - Phosphorylation
MH  - Proto-Oncogene Proteins/biosynthesis
MH  - RNA, Messenger/biosynthesis
MH  - Receptor Protein-Tyrosine Kinases/biosynthesis/*genetics
MH  - Receptor, trkA
MH  - Receptor, trkB
MH  - Receptor, trkC
MH  - Receptors, Growth Factor/genetics
MH  - Receptors, Nerve Growth Factor/biosynthesis/*genetics
MH  - Receptors, Thyroid Hormone/*physiology
MH  - Thyroid Hormones/pharmacology
MH  - Transfection
MH  - Tretinoin/pharmacology
MH  - Tumor Cells, Cultured
EDAT- 1994/04/01 00:00
MHDA- 1994/04/01 00:01
CRDT- 1994/04/01 00:00
PHST- 1994/04/01 00:00 [pubmed]
PHST- 1994/04/01 00:01 [medline]
PHST- 1994/04/01 00:00 [entrez]
PST - ppublish
SO  - Oncogene. 1994 Apr;9(4):1081-9.