PMID- 8134289
OWN - NLM
STAT- MEDLINE
DCOM- 19940418
LR  - 20190818
IS  - 0196-9781 (Print)
IS  - 0196-9781 (Linking)
VI  - 14
IP  - 6
DP  - 1993 Nov-Dec
TI  - Antitumoral cyclic peptide analogues of chlamydocin.
PG  - 1091-3
AB  - A series of cyclic tetrapeptides bearing the bioactive alkylating group on an 
      epsilon-amino-lysyl function have been examined for their antitumoral activity on 
      L1210 and P388 murine leukemia cell lines. One analogue belonging to the 
      chlamydocin family and bearing a beta-chloroethylnitrosourea group was found to 
      be potent at inhibiting L1210 cell proliferation and had a higher therapeutic 
      index than the reference compound bis-beta-chloroethylnitrosourea (BCNU) on the 
      in vivo P388-induced leukemia model.
FAU - Bernardi, E
AU  - Bernardi E
AD  - Laboratoire des Aminoacides et des Peptides, CNRS-URA 468, Universite Montpellier 
      II, France.
FAU - Fauchere, J L
AU  - Fauchere JL
FAU - Atassi, G
AU  - Atassi G
FAU - Viallefont, P
AU  - Viallefont P
FAU - Lazaro, R
AU  - Lazaro R
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Peptides
JT  - Peptides
JID - 8008690
RN  - 0 (Antibiotics, Antineoplastic)
RN  - 0 (Peptides, Cyclic)
RN  - 53342-16-8 (chlamydocin)
RN  - K3Z4F929H6 (Lysine)
SB  - IM
MH  - Amino Acid Sequence
MH  - Animals
MH  - Antibiotics, Antineoplastic/*chemical synthesis/pharmacology
MH  - Drug Screening Assays, Antitumor
MH  - Female
MH  - Leukemia L1210/drug therapy
MH  - Leukemia P388/drug therapy
MH  - Lysine
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Mice, Inbred DBA
MH  - Molecular Sequence Data
MH  - Peptides, Cyclic/chemical synthesis/pharmacology
EDAT- 1993/11/01 00:00
MHDA- 1993/11/01 00:01
CRDT- 1993/11/01 00:00
PHST- 1993/11/01 00:00 [pubmed]
PHST- 1993/11/01 00:01 [medline]
PHST- 1993/11/01 00:00 [entrez]
AID - 0196-9781(93)90160-I [pii]
AID - 10.1016/0196-9781(93)90160-i [doi]
PST - ppublish
SO  - Peptides. 1993 Nov-Dec;14(6):1091-3. doi: 10.1016/0196-9781(93)90160-i.