PMID- 8135015
OWN - NLM
STAT- MEDLINE
DCOM- 19940421
LR  - 20190702
IS  - 0042-4900 (Print)
IS  - 0042-4900 (Linking)
VI  - 134
IP  - 3
DP  - 1994 Jan 15
TI  - Interaction between Streptococcus suis serotype 2 and porcine reproductive and 
      respiratory syndrome virus in specific pathogen-free piglets.
PG  - 60-4
AB  - Secondary specific pathogen-free (sSPF) piglets were inoculated intranasally with 
      Streptococcus suis serotype 2 alone, porcine reproductive and respiratory 
      syndrome virus (PRRSV) alone, or with PRRSV followed by S suis. Uninfected 
      piglets were used as controls. Pigs inoculated with PRRSV (ATCC VR-2332) followed 
      by challenge with a virulent strain (87555) of S suis serotype 2 developed 
      clinical signs, suppurative meningitis and large numbers of S suis in their 
      tissues, including the brain and meninges. Pigs inoculated with PRRSV alone, S 
      suis (87555) alone, or with PRRSV and the DH5 strain of S suis serotype 2 
      (lacking a protein associated with virulence) and the uninfected piglets did not 
      develop clinical signs or lesions or have large numbers of bacteria in their 
      tissues. The results suggest that PRRSV predisposes sSPF pigs to infection and 
      disease caused by virulent S suis serotype 2. Co-infection of piglets with PRRSV 
      and a virulent strain of S suis may provide a useful model for the study of S 
      suis septicaemia and meningitis.
FAU - Galina, L
AU  - Galina L
AD  - Department of Clinical and Population Sciences, University of Minnesota, St Paul 
      55108.
FAU - Pijoan, C
AU  - Pijoan C
FAU - Sitjar, M
AU  - Sitjar M
FAU - Christianson, W T
AU  - Christianson WT
FAU - Rossow, K
AU  - Rossow K
FAU - Collins, J E
AU  - Collins JE
LA  - eng
PT  - Journal Article
PL  - England
TA  - Vet Rec
JT  - The Veterinary record
JID - 0031164
SB  - IM
MH  - Animals
MH  - Arterivirus/*physiology
MH  - Arterivirus Infections/microbiology/*veterinary
MH  - Meningitis/microbiology/pathology/veterinary
MH  - Respiratory Tract Infections/microbiology/*veterinary
MH  - Specific Pathogen-Free Organisms
MH  - Streptococcal Infections/microbiology/*veterinary
MH  - Streptococcus suis/*physiology
MH  - Swine
MH  - Swine Diseases/*microbiology
MH  - Syndrome
EDAT- 1994/01/15 00:00
MHDA- 1994/01/15 00:01
CRDT- 1994/01/15 00:00
PHST- 1994/01/15 00:00 [pubmed]
PHST- 1994/01/15 00:01 [medline]
PHST- 1994/01/15 00:00 [entrez]
AID - 10.1136/vr.134.3.60 [doi]
PST - ppublish
SO  - Vet Rec. 1994 Jan 15;134(3):60-4. doi: 10.1136/vr.134.3.60.