PMID- 8137683
OWN - NLM
STAT- MEDLINE
DCOM- 19940426
LR  - 20221207
IS  - 0149-5992 (Print)
IS  - 0149-5992 (Linking)
VI  - 17
IP  - 2
DP  - 1994 Feb
TI  - Ethnic differences in human leukocyte antigen markers of susceptibility to IDDM.
PG  - 132-7
AB  - OBJECTIVE: To determine whether genetic differences explain the lower risk of 
      developing insulin-dependent diabetes mellitus (IDDM) for Hispanic versus 
      non-Hispanic white children in Colorado. RESEARCH DESIGN AND METHODS: Hispanic (n 
      = 62) and non-Hispanic white (n = 82) subjects with IDDM identified from the 
      Colorado IDDM Registry and healthy, nondiabetic control subjects were recruited. 
      Human leukocyte antigen (HLA) serologic typing and sequence-specific 
      oligonucleotide typing of DQA1 and DQB1 alleles were performed. RESULTS: HLA and 
      allele associations with IDDM were similar in both ethnic groups. HLA-DR3 and 
      HLA-DR4 were more common in IDDM subjects in both ethnic groups. Subjects with 
      DQBl alleles encoding aspartic acid (Asp) in position 57 were less likely to have 
      IDDM, irrespective of ethnic background. HLA-DR3 was less common among Hispanic 
      subjects than non-Hispanic white control subjects (4.4 vs. 17.5%, Hispanics vs. 
      non-Hispanic whites, P = 0.04). CONCLUSIONS: These data suggest that the lower 
      prevalence of HLA-DR3 in the Hispanic population, a pattern consistent with the 
      presence of Amerindian admixture, may explain the lower rate of IDDM in the 
      Hispanic population.
FAU - Cruickshanks, K J
AU  - Cruickshanks KJ
AD  - Department of Preventive Medicine and Biometrics, University of Colorado School 
      of Medicine, Denver.
FAU - Jobim, L F
AU  - Jobim LF
FAU - Lawler-Heavner, J
AU  - Lawler-Heavner J
FAU - Neville, T G
AU  - Neville TG
FAU - Gay, E C
AU  - Gay EC
FAU - Chase, H P
AU  - Chase HP
FAU - Klingensmith, G
AU  - Klingensmith G
FAU - Todd, J A
AU  - Todd JA
FAU - Hamman, R F
AU  - Hamman RF
LA  - eng
GR  - 05357/PHS HHS/United States
GR  - DK-32493/DK/NIDDK NIH HHS/United States
GR  - RR-69/RR/NCRR NIH HHS/United States
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Diabetes Care
JT  - Diabetes care
JID - 7805975
RN  - 0 (HLA-A Antigens)
RN  - 0 (HLA-B Antigens)
RN  - 0 (HLA-D Antigens)
RN  - 0 (HLA-DQ Antigens)
RN  - 0 (HLA-DQ alpha-Chains)
RN  - 0 (HLA-DQ beta-Chains)
RN  - 0 (HLA-DQA1 antigen)
RN  - 0 (HLA-DQB1 antigen)
RN  - 0 (HLA-DR Antigens)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Alleles
MH  - Case-Control Studies
MH  - Child
MH  - Child, Preschool
MH  - Colorado
MH  - Diabetes Mellitus, Type 1/epidemiology/*genetics/*immunology
MH  - Disease Susceptibility
MH  - *Ethnicity
MH  - Female
MH  - HLA-A Antigens/*blood/genetics
MH  - HLA-B Antigens/*blood/genetics
MH  - HLA-D Antigens/*blood/genetics
MH  - HLA-DQ Antigens/blood/genetics
MH  - HLA-DQ alpha-Chains
MH  - HLA-DQ beta-Chains
MH  - HLA-DR Antigens/blood/genetics
MH  - Hispanic or Latino
MH  - Humans
MH  - Male
MH  - Odds Ratio
MH  - Registries
MH  - White People
EDAT- 1994/02/01 00:00
MHDA- 1994/02/01 00:01
CRDT- 1994/02/01 00:00
PHST- 1994/02/01 00:00 [pubmed]
PHST- 1994/02/01 00:01 [medline]
PHST- 1994/02/01 00:00 [entrez]
AID - 10.2337/diacare.17.2.132 [doi]
PST - ppublish
SO  - Diabetes Care. 1994 Feb;17(2):132-7. doi: 10.2337/diacare.17.2.132.