PMID- 8139137
OWN - NLM
STAT- MEDLINE
DCOM- 19940428
LR  - 20131121
IS  - 0385-2385 (Print)
IS  - 0385-2385 (Linking)
VI  - 35
IP  - 11
DP  - 1993 Nov
TI  - The effect of enalapril on proteinuria in patients with chronic 
      glomerulonephritis and renal insufficiency.
PG  - 1249-52
AB  - We evaluated the effect of enalapril on proteinuria in 20 patients with chronic 
      glomerulonephritis (CGN) and renal insufficiency. Patients were accepted into the 
      study according to the following criteria: 1) a serum creatinine (s-Cr) level 
      over 1.5 mg/dl or a creatinine clearance (Ccr) under 70 ml/min; and 2) urinary 
      protein (UP) over 1.0 g/day, expect for the cases with uncontrollable 
      hypertension. We measured total protein (TP), albumin, s-Cr, Ccr, UP, and Ht 
      during the elanapril therapy. After enalapril therapy, UP slowly decreased, and 
      TP and albumin levels increased. The levels of s-Cr and Ccr did not vary. None of 
      the patients required discontinuation of enalapril therapy caused by side 
      effects, such as anemia or hyperkalemia. In conclusion, enalapril has the effect 
      of decreasing in proteinuria and increasing TP and albumin in patients with CGN 
      and renal insufficiency irrespective of the original diseases.
FAU - Yoshida, A
AU  - Yoshida A
AD  - Division of Nephrology, Nagoya Daini Red Cross Hospital, Japan.
FAU - Morozumi, K
AU  - Morozumi K
FAU - Takeda, A
AU  - Takeda A
FAU - Koyama, K
AU  - Koyama K
FAU - Ideura, T
AU  - Ideura T
FAU - Ikeda, M
AU  - Ikeda M
FAU - Oikawa, T
AU  - Oikawa T
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
PL  - Japan
TA  - Nihon Jinzo Gakkai Shi
JT  - Nihon Jinzo Gakkai shi
JID - 7505731
RN  - 69PN84IO1A (Enalapril)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Chronic Disease
MH  - Enalapril/*therapeutic use
MH  - Female
MH  - Glomerulonephritis/*complications
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Proteinuria/*drug therapy
MH  - Renal Insufficiency/*complications
EDAT- 1993/11/01 00:00
MHDA- 1993/11/01 00:01
CRDT- 1993/11/01 00:00
PHST- 1993/11/01 00:00 [pubmed]
PHST- 1993/11/01 00:01 [medline]
PHST- 1993/11/01 00:00 [entrez]
PST - ppublish
SO  - Nihon Jinzo Gakkai Shi. 1993 Nov;35(11):1249-52.