PMID- 8141122
OWN - NLM
STAT- MEDLINE
DCOM- 19940426
LR  - 20190821
IS  - 0361-8609 (Print)
IS  - 0361-8609 (Linking)
VI  - 45
IP  - 2
DP  - 1994 Feb
TI  - Skin manifestation of agnogenic myeloid metaplasia.
PG  - 167-70
AB  - Agnogenic myeloid metaplasia (AMN) with myelofibrosis is a clonal malignancy of 
      the hematopoietic stem cell. The disease is characterized by increased 
      endothelial cell and fibroblast proliferation, resulting in increased deposition 
      of fibronectin, laminin, and collagen in the bone marrow. In advanced disease, 
      extramedullary hematopoiesis (EMH) is invariably seen in the spleen and liver. 
      The lymph nodes are also frequent sites of EMH, but other organs, especially the 
      kidneys, arenals, lungs, pleura, ovaries, gastrointestinal tract, and dura, may 
      also be involved. Skin manifestations are rare. They may present in several ways: 
      erythematous plaques, nodules, diffuse or papular erythema, ulcers, and bullae. 
      Histopathology of these lesions reveals cells from one or more myeloid lineage in 
      the dermis, erythroid, or megakaryocytic series alone or in combination. In rare 
      cases, all three cell lines are demonstrated.
FAU - Loewy, G
AU  - Loewy G
AD  - Department of Medicine, Cabrini Medical Center, New York, New York 10003.
FAU - Mathew, A
AU  - Mathew A
FAU - Distenfeld, A
AU  - Distenfeld A
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - United States
TA  - Am J Hematol
JT  - American journal of hematology
JID - 7610369
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Erythema/*complications
MH  - Female
MH  - Humans
MH  - Male
MH  - Primary Myelofibrosis/*complications
MH  - Skin Diseases, Vesiculobullous/*complications
MH  - Splenectomy
EDAT- 1994/02/01 00:00
MHDA- 1994/02/01 00:01
CRDT- 1994/02/01 00:00
PHST- 1994/02/01 00:00 [pubmed]
PHST- 1994/02/01 00:01 [medline]
PHST- 1994/02/01 00:00 [entrez]
AID - 10.1002/ajh.2830450213 [doi]
PST - ppublish
SO  - Am J Hematol. 1994 Feb;45(2):167-70. doi: 10.1002/ajh.2830450213.