PMID- 8141399
OWN - NLM
STAT- MEDLINE
DCOM- 19940426
LR  - 20171213
IS  - 0002-9513 (Print)
IS  - 0002-9513 (Linking)
VI  - 266
IP  - 2 Pt 2
DP  - 1994 Feb
TI  - Preference and diet type affect macronutrient selection after morphine, NPY, 
      norepinephrine, and deprivation.
PG  - R426-33
AB  - The orexigenic agents morphine, neuropeptide Y (NPY), and norepinephrine (NE) and 
      deprivation have been reported to induce selection of specific macronutrients: 
      fat, carbohydrate (CHO), CHO, and fat, respectively. We utilized analysis of 
      covariance to compensate for the influence of baseline preference on feeding 
      induced by six experimental procedures: morphine, NPY, NE, 24 and 48 h food 
      deprivation, and chronic dietary restriction. Rats received one of two dietary 
      regimens: three macronutrient diets containing CHO, protein, or fat (regimen I) 
      and two nutritionally complete diets that were high CHO or high fat (regimen II). 
      Baseline preference significantly influenced dietary selection after all six 
      experimental procedures studied in regimen I and after NPY, NE, 48 h food 
      deprivation, and chronic dietary restriction in regimen II (covariate P < 0.05). 
      In both dietary regimens, morphine (5 mg/kg) increased consumption of fat, NPY (5 
      micrograms icv) increased selection of CHO, and consumption of all diets was 
      induced equally after NE injections (20 micrograms icv). After 24 or 48 h food 
      deprivation, animals consumed more fat in regimen I and more CHO diet in regimen 
      II. Restricting food intake by 20% increased fat and protein consumption in 
      regimen I but had no effect in regimen II. Diet selection is affected by prior 
      preference, feeding stimulus, and type of diet choice presented.
FAU - Welch, C C
AU  - Welch CC
AD  - Department of Medicine, Department of Veterans Affairs Medical Center, 
      Minneapolis, Minnesota 55417.
FAU - Grace, M K
AU  - Grace MK
FAU - Billington, C J
AU  - Billington CJ
FAU - Levine, A S
AU  - Levine AS
LA  - eng
GR  - DA-03999/DA/NIDA NIH HHS/United States
GR  - DA-07097/DA/NIDA NIH HHS/United States
GR  - DK-42698/DK/NIDDK NIH HHS/United States
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Am J Physiol
JT  - The American journal of physiology
JID - 0370511
RN  - 0 (Dietary Carbohydrates)
RN  - 0 (Dietary Fats)
RN  - 0 (Dietary Proteins)
RN  - 0 (Neuropeptide Y)
RN  - 76I7G6D29C (Morphine)
RN  - X4W3ENH1CV (Norepinephrine)
SB  - IM
MH  - Analysis of Variance
MH  - Animals
MH  - Dietary Carbohydrates
MH  - Dietary Fats
MH  - Dietary Proteins
MH  - Energy Intake
MH  - Feeding Behavior/drug effects
MH  - *Food Deprivation
MH  - *Food Preferences/drug effects
MH  - Male
MH  - Morphine/*pharmacology
MH  - Neuropeptide Y/*pharmacology
MH  - Norepinephrine/*pharmacology
MH  - Rats
MH  - Rats, Sprague-Dawley
EDAT- 1994/02/01 00:00
MHDA- 1994/02/01 00:01
CRDT- 1994/02/01 00:00
PHST- 1994/02/01 00:00 [pubmed]
PHST- 1994/02/01 00:01 [medline]
PHST- 1994/02/01 00:00 [entrez]
AID - 10.1152/ajpregu.1994.266.2.R426 [doi]
PST - ppublish
SO  - Am J Physiol. 1994 Feb;266(2 Pt 2):R426-33. doi: 10.1152/ajpregu.1994.266.2.R426.