PMID- 8143266
OWN - NLM
STAT- MEDLINE
DCOM- 19940505
LR  - 20190816
IS  - 0165-4608 (Print)
IS  - 0165-4608 (Linking)
VI  - 72
IP  - 2
DP  - 1994 Feb
TI  - Tetrasomy 8 as a clonal anomaly in myeloid neoplasias.
PG  - 101-4
AB  - Tetrasomy of chromosome 8 as a sole anomaly is apparently extremely rare in acute 
      non-lymphocytic leukemia (ANLL): Only two cases have been reported, one of ANLL 
      (M5b) with this karyotype. Very recently, another case was reported of a 
      myelodysplastic syndrome (MDS) with isolated tetrasomy 8. We report tetrasomy 8 
      in four cases of ANLL, two of them with M5 and one with M1 subtype. Although in 
      the latter case, tetrasomy 8 was evident in all karyotypes analyzed, in all other 
      cases it constituted a subpopulation of cells other than those with trisomy 8 and 
      those with a normal karyotype (in only one case another change was evident in the 
      karyotype). Using fluorescence in situ hybridization (FISH), the proportion of 
      tetrasomic cells was determined in interphase nuclei. By this technique, small 
      cell populations (3-9%) were detected in three additional trisomy cases. An 
      additional "control" group of five trisomy cases did not show a significant 
      population of tetrasomic interphase nuclei. The data show that tetrasomy 8, if 
      present as a sole anomaly in ANLL, may play a rather specific role for the 
      subtype, and probably for the progression of myeloid neoplasia as well.
FAU - Trautmann, U
AU  - Trautmann U
AD  - Institute f. Humangenetik d. Universitat Erlangen-Nurnberg, Germany.
FAU - Gramatzki, M
AU  - Gramatzki M
FAU - Krauss, M
AU  - Krauss M
FAU - Friz, A
AU  - Friz A
FAU - Liehr, T
AU  - Liehr T
FAU - Gebhart, E
AU  - Gebhart E
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Cancer Genet Cytogenet
JT  - Cancer genetics and cytogenetics
JID - 7909240
SB  - IM
MH  - Adult
MH  - Aged
MH  - *Chromosome Aberrations
MH  - *Chromosomes, Human, Pair 8
MH  - Female
MH  - Humans
MH  - Leukemia, Myeloid, Acute/*genetics
MH  - Male
MH  - Middle Aged
EDAT- 1994/02/01 00:00
MHDA- 1994/02/01 00:01
CRDT- 1994/02/01 00:00
PHST- 1994/02/01 00:00 [pubmed]
PHST- 1994/02/01 00:01 [medline]
PHST- 1994/02/01 00:00 [entrez]
AID - 0165-4608(94)90123-6 [pii]
AID - 10.1016/0165-4608(94)90123-6 [doi]
PST - ppublish
SO  - Cancer Genet Cytogenet. 1994 Feb;72(2):101-4. doi: 10.1016/0165-4608(94)90123-6.