PMID- 8143267
OWN - NLM
STAT- MEDLINE
DCOM- 19940505
LR  - 20190816
IS  - 0165-4608 (Print)
IS  - 0165-4608 (Linking)
VI  - 72
IP  - 2
DP  - 1994 Feb
TI  - Translocation (12;22)(p13;q12) as sole karyotypic abnormality in a patient with 
      nonlymphocytic leukemia.
PG  - 105-8
AB  - Cytogenetic analysis of unstimulated bone marrow (BM) and peripheral blood (PB) 
      cells of a patient with clinical features of atypical chronic myeloid leukemia 
      (CML) showed t(12;22)(p13;q12) as the sole karyotypic abnormality. Subsequent 
      fluorescence in situ hybridization (FISH) with abl- and bcr-specific cosmids as 
      well as chromosome 12- and 22-specific DNA libraries and Southern blot analysis 
      confirmed that in this patient t(12;22) does not constitute a cryptic Ph variant. 
      Recently, a few very similar cases were reported by other investigations. The 
      possible significance of this translocation as a new cytogenetic marker for 
      nonlymphocytic leukemia is discussed.
FAU - Geurts van Kessel, A
AU  - Geurts van Kessel A
AD  - Department of Human Genetics, University Hospital, Nijmegen, The Netherlands.
FAU - Stellink, F
AU  - Stellink F
FAU - van Gaal, J
AU  - van Gaal J
FAU - van de Klundert, W
AU  - van de Klundert W
FAU - Siepman, A
AU  - Siepman A
FAU - Oosten, H R
AU  - Oosten HR
LA  - eng
PT  - Case Reports
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Cancer Genet Cytogenet
JT  - Cancer genetics and cytogenetics
JID - 7909240
RN  - 0 (DNA, Neoplasm)
SB  - IM
MH  - *Chromosomes, Human, Pair 12
MH  - *Chromosomes, Human, Pair 22
MH  - DNA, Neoplasm/analysis
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Leukemia, Myeloid, Acute/*genetics
MH  - Male
MH  - Middle Aged
MH  - *Translocation, Genetic
EDAT- 1994/02/01 00:00
MHDA- 1994/02/01 00:01
CRDT- 1994/02/01 00:00
PHST- 1994/02/01 00:00 [pubmed]
PHST- 1994/02/01 00:01 [medline]
PHST- 1994/02/01 00:00 [entrez]
AID - 0165-4608(94)90124-4 [pii]
AID - 10.1016/0165-4608(94)90124-4 [doi]
PST - ppublish
SO  - Cancer Genet Cytogenet. 1994 Feb;72(2):105-8. doi: 10.1016/0165-4608(94)90124-4.