PMID- 8145047
OWN - NLM
STAT- MEDLINE
DCOM- 19940505
LR  - 20190508
IS  - 0022-1007 (Print)
IS  - 1540-9538 (Electronic)
IS  - 0022-1007 (Linking)
VI  - 179
IP  - 4
DP  - 1994 Apr 1
TI  - Induction of interleukin 4 (IL-4) expression in T helper (Th) cells is not 
      dependent on IL-4 from non-Th cells.
PG  - 1349-53
AB  - Interleukin 4 (IL-4) is essential for the induction of immunoglobulin E (IgE) 
      responses in mice. Recent in vitro studies have suggested that IL-4 derived from 
      non T helper (Th) cells, in particular from mast cells and basophils, may be 
      essential for triggering of IL-4 expression in Th cells and may directly 
      contribute to IgE isotype switch induction. Here, we have generated mice carrying 
      a functional IL-4 gene only in Th cells or non-Th cells, respectively, by 
      reconstitution of IL-4-deficient mice (IL-4T mice) with CD4+ or CD4- spleen cells 
      from congenic wild-type animals. In mice in which only CD4+ cells are able to 
      express IL-4, antigen-specific IgE is produced in a T cell-dependent immune 
      response. Thus, induction of IL-4 expression in Th cells can occur in the absence 
      of IL-4 from non-Th cells, which suggests that at least some Th cells can express 
      IL-4 in response to another signal which has yet to be identified. No IgE is 
      detectable, however, in mice in which only CD4- cells can express IL-4, 
      suggesting that Th cells are the primary, if not the only source of IL-4 for 
      initial induction of IgE synthesis.
FAU - Schmitz, J
AU  - Schmitz J
AD  - Institute for Genetics, University of Cologne, Germany.
FAU - Thiel, A
AU  - Thiel A
FAU - Kuhn, R
AU  - Kuhn R
FAU - Rajewsky, K
AU  - Rajewsky K
FAU - Muller, W
AU  - Muller W
FAU - Assenmacher, M
AU  - Assenmacher M
FAU - Radbruch, A
AU  - Radbruch A
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Exp Med
JT  - The Journal of experimental medicine
JID - 2985109R
RN  - 207137-56-2 (Interleukin-4)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Animals
MH  - Gene Expression Regulation
MH  - Immunoglobulin E/biosynthesis
MH  - Interleukin-4/*biosynthesis/genetics
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - T-Lymphocytes/*metabolism
MH  - T-Lymphocytes, Helper-Inducer/*metabolism
PMC - PMC2191446
EDAT- 1994/04/01 00:00
MHDA- 1994/04/01 00:01
PMCR- 1994/10/01
CRDT- 1994/04/01 00:00
PHST- 1994/04/01 00:00 [pubmed]
PHST- 1994/04/01 00:01 [medline]
PHST- 1994/04/01 00:00 [entrez]
PHST- 1994/10/01 00:00 [pmc-release]
AID - 94194291 [pii]
AID - 10.1084/jem.179.4.1349 [doi]
PST - ppublish
SO  - J Exp Med. 1994 Apr 1;179(4):1349-53. doi: 10.1084/jem.179.4.1349.