PMID- 8146225
OWN - NLM
STAT- MEDLINE
DCOM- 19940502
LR  - 20190712
IS  - 0091-3057 (Print)
IS  - 0091-3057 (Linking)
VI  - 47
IP  - 2
DP  - 1994 Feb
TI  - Hyperactivity in the offspring of nicotine-treated rats: role of the mesolimbic 
      and nigrostriatal dopaminergic pathways.
PG  - 331-7
AB  - To evaluate the involvement of the mesolimbic and nigrostriatal dopaminergic 
      systems in hyperactivity in offspring of nicotine-treated dams, timed-pregnant 
      Sprague-Dawley rats were implanted SC on gestational day 4 with osmotic minipumps 
      to receive saline or nicotine (3 or 6 mg/kg/day) for 16 days. Hyperactive and 
      nonhyperactive male offspring of nicotine-treated dams as well as nonhyperactive 
      offspring of saline-treated dams were selected and sacrificed at day 22 
      postnatally. Discrete brain areas (the nucleus accumbens [NAcc], striatum [STR], 
      frontal cortex [FC], ventral tegmental area [VTA], and substantia nigra [SN]) 
      were microdissected for the evaluation of dopamine (DA) concentration and/or the 
      D2 receptor subtype. Dopamine concentration was decreased in the VTA and STR but 
      was increased in the SN of the hyperactive offspring. The reduction in striatal 
      DA level was associated with a reduction in the number of D2 receptors in that 
      area. The data suggest a role for the VTA and striatal dopaminergic system in 
      offspring hyperactivity.
FAU - Richardson, S A
AU  - Richardson SA
AD  - Department of Pharmacology, Howard University College of Medicine, Washington, DC 
      20059.
FAU - Tizabi, Y
AU  - Tizabi Y
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Pharmacol Biochem Behav
JT  - Pharmacology, biochemistry, and behavior
JID - 0367050
RN  - 0 (Receptors, Dopamine D2)
RN  - 6M3C89ZY6R (Nicotine)
RN  - K5161X06LL (Cotinine)
RN  - VTD58H1Z2X (Dopamine)
SB  - IM
MH  - Animals
MH  - Behavior, Animal/drug effects
MH  - Birth Weight/drug effects
MH  - Brain Chemistry/drug effects
MH  - Corpus Striatum/*physiology
MH  - Cotinine/blood
MH  - Dopamine/*physiology
MH  - Female
MH  - Kinetics
MH  - Limbic System/drug effects/*physiology
MH  - Litter Size/drug effects
MH  - Male
MH  - Motor Activity/*drug effects
MH  - Neural Pathways/drug effects
MH  - Nicotine/blood/*pharmacology
MH  - Pregnancy
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Receptors, Dopamine D2/drug effects
MH  - Sex Ratio
MH  - Substantia Nigra/*physiology
EDAT- 1994/02/01 00:00
MHDA- 1994/02/01 00:01
CRDT- 1994/02/01 00:00
PHST- 1994/02/01 00:00 [pubmed]
PHST- 1994/02/01 00:01 [medline]
PHST- 1994/02/01 00:00 [entrez]
AID - 0091-3057(94)90018-3 [pii]
AID - 10.1016/0091-3057(94)90018-3 [doi]
PST - ppublish
SO  - Pharmacol Biochem Behav. 1994 Feb;47(2):331-7. doi: 10.1016/0091-3057(94)90018-3.