PMID- 8149510
OWN - NLM
STAT- MEDLINE
DCOM- 19940509
LR  - 20031114
IS  - 0092-6213 (Print)
IS  - 0092-6213 (Linking)
VI  - 42
IP  - 1
DP  - 1994 Jan
TI  - Changes in tissue antioxidant enzyme activities and lipid peroxides in 
      endotoxin-induced multiple organ failure.
PG  - 53-8
AB  - Intravenous administration of bacterial endotoxin (lipopolysaccharide: LPS) 
      induces shock and disseminated intravascular coagulation in rats. Our report here 
      shows that LPS-administered rats (10 mg/100 g) develop tissue injuries and 
      functional disorders in multiple vital organs. In the present study, we 
      investigated changes in tissue antioxidant enzyme activities, neutrophil 
      sequestration, and lipid peroxides in multiple organs (lung, stomach, small 
      intestine for antioxidant enzyme activities and neutrophil sequestration; lung, 
      stomach, small intestine, liver, abdominal aorta for lipid peroxides) of 
      LPS-treated rats. LPS-treated animals morphologically revealed pulmonary 
      interstitial edema, alveolar hemorrhage, and mucosal hemorrhage in the small 
      intestine 45 min after LPS administration. Blood samples withdrawn from 
      LPS-treated animals exhibited increases in serum amylase, blood urea nitrogen, 
      creatinine, and transaminase levels up to 180 min post-LPS infusion. LPS-treated 
      animals showed a significant increase in tissue myeloperoxidase (MPO) activities 
      of the lung, but not of the small intestine and stomach 45 min after LPS 
      infusion. Thiobarbituric acid reactive substances (TBARS) in the lung, small 
      intestine, stomach, liver, and abdominal aorta significantly increased at 45 min 
      post-LPS-infusion. Tissue superoxide dismutase (SOD) activities of the 
      LPS-treated animals demonstrated a significant decrease in the lung, which 
      suffered from severe insults and neutrophil sequestration; no significant change 
      in the small intestine, which suffered from morphological insults without 
      neutrophil sequestration, and a significant increase in the stomach, which showed 
      no histological impairment, at 180 min post-LPS administration. Glutathione 
      peroxidase (GSH-PX) activities of the lung and small intestine showed no 
      significant change in LPS-treated rats, while those of the stomach revealed a 
      marked increase.(ABSTRACT TRUNCATED AT 250 WORDS)
FAU - Yoshikawa, T
AU  - Yoshikawa T
AD  - First Department of Medicine, Kyoto Prefectural University of Medicine, Japan.
FAU - Takano, H
AU  - Takano H
FAU - Takahashi, S
AU  - Takahashi S
FAU - Ichikawa, H
AU  - Ichikawa H
FAU - Kondo, M
AU  - Kondo M
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Circ Shock
JT  - Circulatory shock
JID - 0414112
RN  - 0 (Endotoxins)
RN  - 0 (Lipid Peroxides)
RN  - 0 (Thiobarbituric Acid Reactive Substances)
RN  - EC 1.11.1.7 (Peroxidase)
RN  - EC 1.11.1.9 (Glutathione Peroxidase)
RN  - EC 1.15.1.1 (Superoxide Dismutase)
SB  - IM
MH  - Animals
MH  - *Endotoxins
MH  - Glutathione Peroxidase/*metabolism
MH  - Lipid Peroxides/*metabolism
MH  - Male
MH  - Multiple Organ Failure/*chemically induced/*enzymology/pathology
MH  - Peroxidase/metabolism
MH  - Rats
MH  - Rats, Wistar
MH  - Superoxide Dismutase/*metabolism
MH  - Thiobarbituric Acid Reactive Substances/metabolism
EDAT- 1994/01/01 00:00
MHDA- 1994/01/01 00:01
CRDT- 1994/01/01 00:00
PHST- 1994/01/01 00:00 [pubmed]
PHST- 1994/01/01 00:01 [medline]
PHST- 1994/01/01 00:00 [entrez]
PST - ppublish
SO  - Circ Shock. 1994 Jan;42(1):53-8.