PMID- 8151264
OWN - NLM
STAT- MEDLINE
DCOM- 19940512
LR  - 20220321
IS  - 0954-6820 (Print)
IS  - 0954-6820 (Linking)
VI  - 235
IP  - 4
DP  - 1994 Apr
TI  - Continuous infusion of furosemide in the treatment of patients with congestive 
      heart failure and diuretic resistance.
PG  - 329-34
AB  - OBJECTIVES: To assess the value of treatment with continuous intravenous infusion 
      of furosemide (F) in patients with refractory congestive heart failure. DESIGN: 
      Open uncontrolled dose-response study. SUBJECTS: Patients with congestive heart 
      failure (those with New York Heart Association (NYHA) classes III and IV with an 
      assessed amount of oedema of more than 5 kg and diuretic resistance were included 
      [n = 10]). Diuretic resistance was defined as: failure to lose weight and/or 
      inappropriate urinary sodium excretion (50 mmol 24 h-1) despite bed rest for a 
      period of 2-3 days, salt and water restriction, orally and intravenously 
      administered furosemide in a dose of 250 mg day-1, digoxin, and when possible an 
      ACE inhibitor. Included patients were treated with continuous F infusion at a 
      delivery rate of 20 mg-1 over 24 h. The infusion rate was gradually heightened up 
      to a maximum dose of 160 mg h-1. MAIN OUTCOME MEASURES: Daily physical 
      examination, history of side-effects, determination of serum electrolytes and 
      24-h electrolyte excretion during treatment with furosemide. RESULTS: Weight loss 
      (mean +/- SD; 12.5 +/- 5 kg) and relief of symptoms was achieved in all patients. 
      Mean (+/- SD) 24-h sodium output rose from 19 +/- 16 mmol 24 h-1 (n = 10) on oral 
      therapy with 250 mg F to 137 +/- 85 mmol 24 h-1 (n = 8) during 80 mg h-1 and to 
      268 +/- 124 mmol 24 h-1 (n = 3) on the maximal dose of 160 mg h-1. CONCLUSION: 
      Continuous infusion of F under careful monitoring of the patient is a safe, 
      controllable and efficient treatment in patients with severe congestive heart 
      failure and diuretic resistance.
FAU - van Meyel, J J
AU  - van Meyel JJ
AD  - Department of Pharmacology, University of Nijmegen, Netherlands.
FAU - Smits, P
AU  - Smits P
FAU - Dormans, T
AU  - Dormans T
FAU - Gerlag, P G
AU  - Gerlag PG
FAU - Russel, F G
AU  - Russel FG
FAU - Gribnau, F W
AU  - Gribnau FW
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
PL  - England
TA  - J Intern Med
JT  - Journal of internal medicine
JID - 8904841
RN  - 0 (Diuretics)
RN  - 7LXU5N7ZO5 (Furosemide)
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Diuretics/therapeutic use
MH  - Drug Administration Schedule
MH  - Drug Resistance
MH  - Female
MH  - Furosemide/*administration & dosage/pharmacokinetics
MH  - Heart Failure/*drug therapy/metabolism
MH  - Humans
MH  - Infusions, Intravenous
MH  - Male
MH  - Middle Aged
MH  - Treatment Outcome
EDAT- 1994/04/01 00:00
MHDA- 1994/04/01 00:01
CRDT- 1994/04/01 00:00
PHST- 1994/04/01 00:00 [pubmed]
PHST- 1994/04/01 00:01 [medline]
PHST- 1994/04/01 00:00 [entrez]
AID - 10.1111/j.1365-2796.1994.tb01082.x [doi]
PST - ppublish
SO  - J Intern Med. 1994 Apr;235(4):329-34. doi: 10.1111/j.1365-2796.1994.tb01082.x.