PMID- 8152251 OWN - NLM STAT- MEDLINE DCOM- 19940510 LR - 20220331 IS - 0887-6924 (Print) IS - 0887-6924 (Linking) VI - 8 IP - 4 DP - 1994 Apr TI - The t(14;18) in a patient with de novo acute lymphoblastic leukemia is associated with t(8;9). PG - 560-3 AB - Cytogenetic analysis of a bone marrow aspirate from a patient with acute lymphoblastic leukemia (ALL) revealed the presence of a complex karyotype containing the translocation, t(14;18)(q32;q21). Further investigations using fluorescence in situ hybridization (FISH) allowed the characterization of an additional translocation, t(8;9)(q24;p1?). The association of t(14;18)(q32;q21) and t(8;9)(q24;p13) has recently been described in two patients with de novo ALL (Nacheva et al. Blood 1993;82:231-240) and this report supports these findings. FAU - Lillington, D M AU - Lillington DM AD - ICRF Department of Medical Oncology, St Bartholomew's Hospital, London, UK. FAU - Monard, S AU - Monard S FAU - Johnson, P W AU - Johnson PW FAU - Evans, M L AU - Evans ML FAU - Kearney, L U AU - Kearney LU FAU - Lister, T A AU - Lister TA FAU - Young, B D AU - Young BD FAU - Gibbons, B AU - Gibbons B LA - eng PT - Case Reports PT - Journal Article PL - England TA - Leukemia JT - Leukemia JID - 8704895 SB - IM MH - Adult MH - *Chromosomes, Human, Pair 14 MH - *Chromosomes, Human, Pair 18 MH - *Chromosomes, Human, Pair 8 MH - *Chromosomes, Human, Pair 9 MH - Humans MH - In Situ Hybridization, Fluorescence MH - Karyotyping MH - Male MH - Precursor Cell Lymphoblastic Leukemia-Lymphoma/*genetics MH - *Translocation, Genetic EDAT- 1994/04/01 00:00 MHDA- 1994/04/01 00:01 CRDT- 1994/04/01 00:00 PHST- 1994/04/01 00:00 [pubmed] PHST- 1994/04/01 00:01 [medline] PHST- 1994/04/01 00:00 [entrez] PST - ppublish SO - Leukemia. 1994 Apr;8(4):560-3.