PMID- 8152254
OWN - NLM
STAT- MEDLINE
DCOM- 19940510
LR  - 20130304
IS  - 0887-6924 (Print)
IS  - 0887-6924 (Linking)
VI  - 8
IP  - 4
DP  - 1994 Apr
TI  - Hunting 11q23 deletions with fluorescence in situ hybridization (FISH).
PG  - 578-86
AB  - Seven patients with acute leukemia and translocation involving band 11q23 have 
      been studied by fluorescence in situ hybridization (FISH) using YAC probes 
      spanning the HRX gene. While hybridization signal was split by translocation 
      between the rearranged 11 and the partner chromosomes in five patients, only one 
      signal on the derivative 11 was observed in two patients, one with 
      t(9;11)(p21-22;q23) and the other with t(6;11)(q27;q23). Having shown that HRX 
      was rearranged in these two cases, the distal part of 11q23 was investigated 
      using other YACs containing markers for this region. This showed that a 600-700 
      kb deletion, distal to the HRX breakpoint cluster region, had occurred in the two 
      cases. This study supports the notion that the 5' end of HRX is the important 
      part in the chimeric genes resulting from 11q23 translocations and suggests that 
      deletions of the 3' part are not uncommon.
FAU - Cherif, D
AU  - Cherif D
AD  - Unite INSERM U 301, Paris, France.
FAU - Bernard, O
AU  - Bernard O
FAU - Paulien, S
AU  - Paulien S
FAU - James, M R
AU  - James MR
FAU - Le Paslier, D
AU  - Le Paslier D
FAU - Berger, R
AU  - Berger R
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Leukemia
JT  - Leukemia
JID - 8704895
SB  - IM
GS  - HRX
MH  - Adult
MH  - Base Sequence
MH  - Child
MH  - *Chromosome Deletion
MH  - Chromosome Mapping
MH  - *Chromosomes, Human, Pair 11
MH  - Chromosomes, Human, Pair 4
MH  - Chromosomes, Human, Pair 6
MH  - Chromosomes, Human, Pair 9
MH  - Female
MH  - Gene Rearrangement
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Infant
MH  - Leukemia, Monocytic, Acute/*genetics
MH  - Male
MH  - Molecular Sequence Data
MH  - Precursor Cell Lymphoblastic Leukemia-Lymphoma/*genetics
MH  - *Translocation, Genetic
EDAT- 1994/04/01 00:00
MHDA- 1994/04/01 00:01
CRDT- 1994/04/01 00:00
PHST- 1994/04/01 00:00 [pubmed]
PHST- 1994/04/01 00:01 [medline]
PHST- 1994/04/01 00:00 [entrez]
PST - ppublish
SO  - Leukemia. 1994 Apr;8(4):578-86.