PMID- 8152310
OWN - NLM
STAT- MEDLINE
DCOM- 19940506
LR  - 20130304
IS  - 0887-6924 (Print)
IS  - 0887-6924 (Linking)
VI  - 8 Suppl 1
DP  - 1994 Apr
TI  - Some epidemiological features of the human T-cell lymphotropic virus type I 
      (HTLV-I) and ATL in Nigerians.
PG  - S77-82
AB  - With a seroprevalence rate (SPR) of 6%-10% among healthy adult blood donors 
      (ABD), Nigeria and other African locales represent an endemic zone for HTLV-I. We 
      studied SPR in patients with leukaemia, lymphomas, solid tumours, and chronic 
      disorders, as well as in groups of men and women with varying sexual lifestyles. 
      Serum specimens were screened with ELISA and then confirmed with Western blot 
      (WB). Sexual practices were investigated among volunteers of different sexual 
      backgrounds by means of a questionnaire. Female prostitutes (FP) (13.0%) and 
      patients with sexually transmitted diseases (STDP) (16.7%) had the highest SPR 
      while a low rate occurred in religious celibate males (RCM) but not in religious 
      celibate females (RCF) (11.8%). Heterosexual activity as well as geographical 
      location of the place of birth constituted the most important risk factors for 
      HTLV-I. HIV antibodies were demonstrable in none of the study subjects. ATL was 
      associated with 100% SPR (4/4) while SPR in other clinical states were not 
      different from normal. Western blot profile was rarely of strong poly band but 
      more frequently of weak oligo band pattern with absent or weak p19 compared to 
      p24. Only 18% of non Hodgkin's lymphoma in Ibadan, Nigeria was seropositive 
      compared to 50% and > 60% in Japanese and Caribbean endemic zones respectively. 
      The high SPR and aberrant WB profiles indicate reactivity to HTLV-I and to an 
      HTLV-II-like activity, probably a new virus in the region. Excluding the aberrant 
      WB profile, SPR based on HTLV-I-related profile was 3.8%-4.8% in ABD, 13% in FP, 
      10% in STDP, 1.9% in RCM, 0% in RCF, and 25% in ATL patients. The HTLV-II-related 
      profile showed no such heterosexual association, but occurred in 75% of ATL 
      patients. HTLV-I and probably and an HTLV-II-like virus appear to play a role in 
      STD and lymphoma epidemiology in Nigeria.
FAU - Williams, C K
AU  - Williams CK
AD  - Allan Blair Memorial Clinic, Saskatchewan Cancer Foundation, Regina, Canada.
FAU - Dada, A
AU  - Dada A
FAU - Blattner, W A
AU  - Blattner WA
LA  - eng
GR  - N01 CP 51030/CP/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - England
TA  - Leukemia
JT  - Leukemia
JID - 8704895
RN  - 0 (HTLV-I Antibodies)
SB  - IM
MH  - Adult
MH  - Female
MH  - HTLV-I Antibodies/*blood
MH  - Human T-lymphotropic virus 1/isolation & purification
MH  - Human T-lymphotropic virus 2/isolation & purification
MH  - Humans
MH  - Leukemia-Lymphoma, Adult T-Cell/*epidemiology
MH  - Male
MH  - Nigeria/epidemiology
MH  - Prevalence
EDAT- 1994/04/01 00:00
MHDA- 1994/04/01 00:01
CRDT- 1994/04/01 00:00
PHST- 1994/04/01 00:00 [pubmed]
PHST- 1994/04/01 00:01 [medline]
PHST- 1994/04/01 00:00 [entrez]
PST - ppublish
SO  - Leukemia. 1994 Apr;8 Suppl 1:S77-82.