PMID- 8155719
OWN - NLM
STAT- MEDLINE
DCOM- 19940519
LR  - 20190610
IS  - 0006-3002 (Print)
IS  - 0006-3002 (Linking)
VI  - 1212
IP  - 1
DP  - 1994 Apr 14
TI  - Nagase analbuminemic rats have faster plasma triacylglycerol and VLDL synthesis 
      rates.
PG  - 103-8
AB  - Serum triacylglycerol (TG) concentration is markedly elevated in Nagase 
      analbuminemic rats (NAR) as compared to Sprague-Dawley rats (SDR) and reflects a 
      high level of mainly VLDL. Hepatic production of triacylglycerol, as measured by 
      the Triton-WR1339 infusion technique of impairing TG removal from blood, and 
      plasma metabolic rate of pulse-infused [125I]apo VLDL, were higher in NAR. 
      However, contrary to previous reports, this elevated TG production could not be 
      controlled by previous treatment of NAR with (i) bovine albumin infused 
      intra-arterially or into the peritoneal cavity, or with (ii) dextran (Mol.wt. 
      73,500) injected intraperitoneally. Albumin administration expanded the plasma 
      volume and could explain the apparent reduction of blood lipids found by others. 
      Nonetheless, intraperitoneal dextran, as compared to saline, reduced the plasma 
      cholesterol concentration regardless of the variation in the hematocrit level and 
      thus, by raising the osmotic pressure of blood might regulate the metabolism of 
      cholesterol-rich lipoproteins such as LDL and HDL in NAR.
FAU - Catanozzi, S
AU  - Catanozzi S
AD  - Lipid Lab. LIM/10, Univ. Sao Paulo Medical School, Brazil.
FAU - Rocha, J C
AU  - Rocha JC
FAU - Nakandakare, E R
AU  - Nakandakare ER
FAU - Oliveira, H C
AU  - Oliveira HC
FAU - Quintao, E C
AU  - Quintao EC
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - Biochim Biophys Acta
JT  - Biochimica et biophysica acta
JID - 0217513
RN  - 0 (Lipoproteins, VLDL)
RN  - 0 (Serum Albumin)
RN  - 0 (Triglycerides)
SB  - IM
MH  - Animals
MH  - Kinetics
MH  - Lipoproteins, VLDL/*biosynthesis/blood
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Serum Albumin/*deficiency
MH  - Species Specificity
MH  - Triglycerides/*biosynthesis/blood
EDAT- 1994/04/14 00:00
MHDA- 1994/04/14 00:01
CRDT- 1994/04/14 00:00
PHST- 1994/04/14 00:00 [pubmed]
PHST- 1994/04/14 00:01 [medline]
PHST- 1994/04/14 00:00 [entrez]
AID - 0005-2760(94)90194-5 [pii]
AID - 10.1016/0005-2760(94)90194-5 [doi]
PST - ppublish
SO  - Biochim Biophys Acta. 1994 Apr 14;1212(1):103-8. doi: 
      10.1016/0005-2760(94)90194-5.