PMID- 8156503
OWN - NLM
STAT- MEDLINE
DCOM- 19940513
LR  - 20190620
IS  - 0008-543X (Print)
IS  - 0008-543X (Linking)
VI  - 73
IP  - 6
DP  - 1994 Mar 15
TI  - Clonal chromosomal abnormalities in osteofibrous dysplasia. Implications for 
      histopathogenesis and its relationship with adamantinoma.
PG  - 1746-52
AB  - BACKGROUND: The pathogenesis of osteofibrous dysplasia, a rare fibroosseous 
      lesion occurring almost exclusively in the tibia of children younger than 10 
      years of age, is not known. One theory is that osteofibrous dysplasia results 
      from excessive resorption of bone with fibrous repair of the defect. 
      Alternatively, osteofibrous dysplasia has been considered a congenital lesion or 
      a variant of fibrous dysplasia. It has been hypothesized that osteofibrous 
      dysplasia is a secondary reactive process to adamantinoma. Cytogenetic analysis 
      is one form of investigation that has been instrumental in determining the origin 
      of many disorders. METHODS: Short-term cultures of two separate osteofibrous 
      dysplasia specimens (approximately 1 year apart) from the tibia of an 11-year-old 
      boy and 2 separate specimens (approximately 2 years apart) from the tibia of a 
      16-year-old boy were cytogenetically examined using standard procedures. 
      Additionally, fluorescence in situ hybridization (FISH) studies were performed on 
      uncultured cells of both specimens of the first patient using an alpha-satellite 
      probe for chromosome 12. RESULTS: Cytogenetic and FISH analysis revealed trisomy 
      12 in both specimens of the first patient. Trisomy for chromosomes 7, 8, and 22 
      was seen in both specimens of the second patient. CONCLUSIONS: Osteofibrous 
      dysplasia has not previously been subjected to cytogenetic analysis. Trisomy 7 
      and 12, however, have been reported in a clonally aberrant adamantinoma, 
      potentially providing further support for a relationship between these two 
      lesions. Most importantly, these findings demonstrate a clonal and possibly 
      neoplastic origin for osteofibrous dysplasia of long bone.
FAU - Bridge, J A
AU  - Bridge JA
AD  - Department of Pathology and Microbiology, University of Nebraska Medical Center, 
      Omaha.
FAU - Dembinski, A
AU  - Dembinski A
FAU - DeBoer, J
AU  - DeBoer J
FAU - Travis, J
AU  - Travis J
FAU - Neff, J R
AU  - Neff JR
LA  - eng
PT  - Case Reports
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Cancer
JT  - Cancer
JID - 0374236
SB  - IM
MH  - Adolescent
MH  - Bone Neoplasms/*genetics/pathology
MH  - Child
MH  - Chromosome Aberrations/*genetics/pathology
MH  - Chromosome Disorders
MH  - Chromosomes, Human, Pair 12
MH  - Chromosomes, Human, Pair 7
MH  - Chromosomes, Human, Pair 8
MH  - Fibroma, Ossifying/*genetics/pathology
MH  - Humans
MH  - Male
MH  - Neoplasms, Glandular and Epithelial/*genetics/pathology
MH  - Tibia/*pathology
MH  - Trisomy/genetics/pathology
EDAT- 1994/03/15 00:00
MHDA- 1994/03/15 00:01
CRDT- 1994/03/15 00:00
PHST- 1994/03/15 00:00 [pubmed]
PHST- 1994/03/15 00:01 [medline]
PHST- 1994/03/15 00:00 [entrez]
AID - 10.1002/1097-0142(19940315)73:6<1746::aid-cncr2820730632>3.0.co;2-w [doi]
PST - ppublish
SO  - Cancer. 1994 Mar 15;73(6):1746-52. doi: 
      10.1002/1097-0142(19940315)73:6<1746::aid-cncr2820730632>3.0.co;2-w.