PMID- 8156951
OWN - NLM
STAT- MEDLINE
DCOM- 19940518
LR  - 20211203
IS  - 0013-9580 (Print)
IS  - 0013-9580 (Linking)
VI  - 35
IP  - 2
DP  - 1994 Mar-Apr
TI  - Is HLA-DRW13 (W6) associated with juvenile myoclonic epilepsy in Arab patients?
PG  - 319-21
AB  - In a study of 32 unrelated Arab patients with juvenile myoclonic epilepsy (JME), 
      we compared the frequencies of human leukocyte antigen (HLA) class I and II 
      alleles with those of unrelated healthy controls. A significant difference 
      between the phenotypic frequencies in JME patients and controls was observed for 
      DRW13, the split of DRW6 (37.5 vs 11% of controls). The strength of association 
      as measured by the relative risk was 4.85 for this antigen (p = 0.002). The 
      possible association of JME with HLA-DRW6 recently reported in Caucasians was 
      confirmed in this study. This finding speaks for the homogeneity of the disease 
      among Arabic and Caucasian JME patients. The existence of this association is 
      evidence of a locus in the HLA region that influences expression of JME.
FAU - Obeid, T
AU  - Obeid T
AD  - Department of Medicine, College of Medicine, KKUH, King Saud University, Riyadh, 
      Saudi Arabia.
FAU - el Rab, M O
AU  - el Rab MO
FAU - Daif, A K
AU  - Daif AK
FAU - Panayiotopoulos, C P
AU  - Panayiotopoulos CP
FAU - Halim, K
AU  - Halim K
FAU - Bahakim, H
AU  - Bahakim H
FAU - Bamgboye, E
AU  - Bamgboye E
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Epilepsia
JT  - Epilepsia
JID - 2983306R
RN  - 0 (HLA-DR Antigens)
RN  - 0 (HLA-DR Serological Subtypes)
RN  - 0 (HLA-DR13 antigen)
RN  - 0 (HLA-DR6 Antigen)
SB  - IM
MH  - Epilepsies, Myoclonic/*genetics/immunology
MH  - HLA-DR Antigens/*genetics
MH  - HLA-DR Serological Subtypes
MH  - HLA-DR6 Antigen/*genetics/immunology
MH  - Histocompatibility Testing
MH  - Humans
MH  - Racial Groups/*genetics
MH  - Risk
MH  - Saudi Arabia/ethnology
EDAT- 1994/03/01 00:00
MHDA- 1994/03/01 00:01
CRDT- 1994/03/01 00:00
PHST- 1994/03/01 00:00 [pubmed]
PHST- 1994/03/01 00:01 [medline]
PHST- 1994/03/01 00:00 [entrez]
AID - 10.1111/j.1528-1157.1994.tb02437.x [doi]
PST - ppublish
SO  - Epilepsia. 1994 Mar-Apr;35(2):319-21. doi: 10.1111/j.1528-1157.1994.tb02437.x.