PMID- 8157969
OWN - NLM
STAT- MEDLINE
DCOM- 19940513
LR  - 20071114
IS  - 0022-1767 (Print)
IS  - 0022-1767 (Linking)
VI  - 152
IP  - 9
DP  - 1994 May 1
TI  - The resolution of acute malaria in a definitive model of B cell deficiency, the 
      JHD mouse.
PG  - 4557-62
AB  - Because the role of cell-mediated immunity (CMI) in the resolution of blood-stage 
      malaria remains unclear, we examined the question of whether mice completely 
      lacking Ab-mediated immunity (AMI) but possessing some CMI can resolve 
      experimental malaria previously reported not to require AMI for resolution. 
      Severe combined immunodeficient mice reconstituted with enriched immune T cells 
      (< 0.5% B220+ cells) suppressed acute Plasmodium chabaudi adami parasitemia, 
      suggesting that T, but not B, cells are required to clear this form of malaria. 
      In addition, JHD mice, which are a definitive model of B cell deficiency, were 
      also shown to resolve P. chabaudi adami, Plasmodium vinckei petteri and 
      Plasmodium chabaudi chabaudi malaria. These observations collectively establish 
      that CMI alone can mediate the clearance of acute malaria caused by these 
      subspecies of Plasmodium. Moreover, the protective cell-mediated immune response 
      involved depends upon CD4+ T cells because JHD mice treated with anti-CD4 mAb do 
      not resolve their infections. These results suggest that evaluation of 
      immunization regimens to activate CD4+ T cell dependent cell mediated immunity 
      against Plasmodium falciparum may be appropriate.
FAU - van der Heyde, H C
AU  - van der Heyde HC
AD  - Department of Medical Microbiology and Immunology, University of Wisconsin, 
      Madison 53706.
FAU - Huszar, D
AU  - Huszar D
FAU - Woodhouse, C
AU  - Woodhouse C
FAU - Manning, D D
AU  - Manning DD
FAU - Weidanz, W P
AU  - Weidanz WP
LA  - eng
GR  - AI 12710/AI/NIAID NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - J Immunol
JT  - Journal of immunology (Baltimore, Md. : 1950)
JID - 2985117R
RN  - 0 (Antibodies, Protozoan)
SB  - IM
MH  - Animals
MH  - Antibodies, Protozoan
MH  - B-Lymphocytes/*immunology
MH  - Disease Models, Animal
MH  - Female
MH  - Immunologic Deficiency Syndromes/complications/*immunology
MH  - Malaria/complications/*immunology
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - Mice, Inbred C57BL
MH  - Mice, Mutant Strains
MH  - Mice, SCID
MH  - Plasmodium/immunology
MH  - T-Lymphocytes/immunology
EDAT- 1994/05/01 00:00
MHDA- 1994/05/01 00:01
CRDT- 1994/05/01 00:00
PHST- 1994/05/01 00:00 [pubmed]
PHST- 1994/05/01 00:01 [medline]
PHST- 1994/05/01 00:00 [entrez]
PST - ppublish
SO  - J Immunol. 1994 May 1;152(9):4557-62.