PMID- 8160769
OWN - NLM
STAT- MEDLINE
DCOM- 19940516
LR  - 20181113
IS  - 0002-9440 (Print)
IS  - 1525-2191 (Electronic)
IS  - 0002-9440 (Linking)
VI  - 144
IP  - 4
DP  - 1994 Apr
TI  - Hepatocyte growth factor/scatter factor expression in human mammary epithelium.
PG  - 675-82
AB  - This study reports expression of mRNA for the growth modulator hepatocyte growth 
      factor/scatter factor (HGF/SF) in both benign and malignant human mammary 
      epithelium by in situ hybridization. In benign breast tissue expression was 
      prominent in areas of adenosis and in peripheral acinic cells in lactating 
      breast; in malignant epithelium expression was seen in 15 of 21 cases of in situ 
      and invasive breast cancer. In some cases of invasive ductal carcinoma stronger 
      labeling appeared to be associated with areas of tubule formation compared with 
      areas of infiltrating growth, although this was not a universal finding. In 
      contrast, two examples each of in situ comedo carcinoma and invasive lobular 
      carcinoma were completely negative. HGF/SF mRNA extracted from a breast tumor 
      demonstrated the expected 6-kb transcript on Northern blot analysis. These 
      findings suggest the possibility of an autocrine loop for action of HGF/SF in 
      proliferating mammary epithelium.
FAU - Wang, Y
AU  - Wang Y
AD  - Department of Medicine, Royal Postgraduate Medical School, London, United 
      Kingdom.
FAU - Selden, A C
AU  - Selden AC
FAU - Morgan, N
AU  - Morgan N
FAU - Stamp, G W
AU  - Stamp GW
FAU - Hodgson, H J
AU  - Hodgson HJ
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Am J Pathol
JT  - The American journal of pathology
JID - 0370502
RN  - 0 (RNA, Messenger)
RN  - 67256-21-7 (Hepatocyte Growth Factor)
SB  - IM
MH  - Blotting, Northern
MH  - Breast/chemistry/*metabolism
MH  - Breast Neoplasms/chemistry/*metabolism
MH  - Carcinoma/chemistry/*metabolism
MH  - Epithelium/metabolism
MH  - Female
MH  - Fibroadenoma/chemistry/*metabolism
MH  - Gene Expression
MH  - Hepatocyte Growth Factor/isolation & purification/*metabolism
MH  - Humans
MH  - Immunoenzyme Techniques
MH  - In Situ Hybridization
MH  - Lactation
MH  - Menopause
MH  - RNA, Messenger/isolation & purification/*metabolism
PMC - PMC1887246
EDAT- 1994/04/01 00:00
MHDA- 1994/04/01 00:01
PMCR- 1994/10/01
CRDT- 1994/04/01 00:00
PHST- 1994/04/01 00:00 [pubmed]
PHST- 1994/04/01 00:01 [medline]
PHST- 1994/04/01 00:00 [entrez]
PHST- 1994/10/01 00:00 [pmc-release]
PST - ppublish
SO  - Am J Pathol. 1994 Apr;144(4):675-82.