PMID- 8164511
OWN - NLM
STAT- MEDLINE
DCOM- 19940523
LR  - 20190825
IS  - 0169-328X (Print)
IS  - 0169-328X (Linking)
VI  - 21
IP  - 1-2
DP  - 1994 Jan
TI  - Cerebral hemidecortication alters expression of transforming growth factor alpha 
      mRNA in the neostriatum of developing rats.
PG  - 107-14
AB  - Transforming growth factor alpha (TGF alpha) is a mitogenic polypeptide which 
      acts at the epidermal growth factor receptor to produce its biologic effects. 
      Recent studies have demonstrated that TGF alpha may act as a neurotrophic factor. 
      Cerebral hemispherectomy (hemidecortication) is performed on some children with 
      intractable epilepsy. Prior studies have demonstrated improved functional 
      recovery in both children and animals when the surgery is performed at a very 
      early age. In order to test whether TGF alpha may be involved in the functional 
      recovery of the neostriatum following cerebral hemidecortication, we performed in 
      situ hybridization for TGF alpha mRNA on brains of rats which underwent 
      hemispherectomy at postnatal day (P) 6 or P12 or in adulthood, and sacrificed 
      one, 7, or 30 days following surgery. Normal striatal expression in control 
      animals was very high at P6 and then decreased throughout development. In animals 
      undergoing lesion at earlier ages (P6 and P12), TGF alpha mRNA expression was 
      first depressed in the ipsilateral neostriatum one day after surgery and then 
      elevated to supranormal levels 7 and 30 days after surgery. Maximal decreases 
      (40% below contralateral neostriatum) were seen in animals lesioned at P12 and 
      sacrificed the next day. Maximal elevations (60% greater than opposite 
      neostriatum) were seen in animals operated on at P6 and sacrificed 30 days post 
      surgery. Expression in the adult animal was only mildly affected, with a 20% 
      increase found in the ipsilateral caudate 7 days after the lesion, but no 
      significant changes after one or 30 days survival.(ABSTRACT TRUNCATED AT 250 
      WORDS)
FAU - Kornblum, H I
AU  - Kornblum HI
AD  - Department of Pediatrics, UCLA School of Medicine 90024.
FAU - Chugani, H T
AU  - Chugani HT
FAU - Tatsukawa, K
AU  - Tatsukawa K
FAU - Gall, C M
AU  - Gall CM
LA  - eng
GR  - MH00974/MH/NIMH NIH HHS/United States
GR  - NS 26748/NS/NINDS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - Netherlands
TA  - Brain Res Mol Brain Res
JT  - Brain research. Molecular brain research
JID - 8908640
RN  - 0 (RNA, Messenger)
RN  - 0 (Transforming Growth Factor alpha)
SB  - IM
MH  - Aging/*metabolism
MH  - Animals
MH  - Animals, Newborn
MH  - Caudate Nucleus/growth & development/*metabolism
MH  - Cerebral Cortex/growth & development/*physiology
MH  - Female
MH  - *Gene Expression
MH  - Male
MH  - Neostriatum/growth & development/*metabolism
MH  - RNA, Messenger/*biosynthesis/metabolism
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Transforming Growth Factor alpha/*biosynthesis
EDAT- 1994/01/01 00:00
MHDA- 1994/01/01 00:01
CRDT- 1994/01/01 00:00
PHST- 1994/01/01 00:00 [pubmed]
PHST- 1994/01/01 00:01 [medline]
PHST- 1994/01/01 00:00 [entrez]
AID - 0169-328X(94)90383-2 [pii]
AID - 10.1016/0169-328x(94)90383-2 [doi]
PST - ppublish
SO  - Brain Res Mol Brain Res. 1994 Jan;21(1-2):107-14. doi: 
      10.1016/0169-328x(94)90383-2.