PMID- 8165365
OWN - NLM
STAT- MEDLINE
DCOM- 19940523
LR  - 20161123
IS  - 0034-5164 (Print)
IS  - 0034-5164 (Linking)
VI  - 83
IP  - 1
DP  - 1994 Jan
TI  - Relationship between anti-aversive effects of salmon calcitonin and plasma levels 
      of ACTH, beta-endorphin and prostaglandin E2 in mice.
PG  - 15-24
AB  - We investigated whether the anti-aversive effects of salmon calcitonin (SCT) was 
      induced by increasing ACTH and beta-endorphin and/or by decreasing of 
      prostaglandin E2 (PGE2) levels in plasma of mice to elucidate the mechanisms 
      responsible for the analgesic effects of SCT. Intracerebroventricular (i.c.v.) 
      injections of SCT inhibited acetic acid-induced aversive behavior (writhing) in a 
      U-shaped dose response curve, the most effective dose being 0.1 IU/mouse. 
      Intraperitoneal (i.p.) injections of acetic acid increased, but not 
      significantly, the levels of plasma ACTH and PGE2, but not beta-endorphin, which 
      are considered to be psychoneuroendocrines correlated with pain. SCT (0.1 
      IU/mouse, i.c.v.) significantly increased plasma ACTH levels (p < 0.05) and 
      tended to increase beta-endorphin levels (p = 0.052) in acetic acid-treated mice, 
      whereas no change in PGE2 level was observed (p > 0.1). These results suggest 
      that the anti-aversive effects of SCT may be mediated, at least in part, by the 
      activation of ACTH.
FAU - Maeda, Y
AU  - Maeda Y
AD  - Department of Neuropsychopharmacology, Nagoya University School of Medicine, 
      Japan.
FAU - Yamada, K
AU  - Yamada K
FAU - Hasegawa, T
AU  - Hasegawa T
FAU - Kawamata, Y
AU  - Kawamata Y
FAU - Uchida, K
AU  - Uchida K
FAU - Iyo, M
AU  - Iyo M
FAU - Fukui, S
AU  - Fukui S
FAU - Nabeshima, T
AU  - Nabeshima T
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Res Commun Chem Pathol Pharmacol
JT  - Research communications in chemical pathology and pharmacology
JID - 0244734
RN  - 0 (Acetates)
RN  - 0 (Analgesics)
RN  - 60617-12-1 (beta-Endorphin)
RN  - 7SFC6U2VI5 (salmon calcitonin)
RN  - 9002-60-2 (Adrenocorticotropic Hormone)
RN  - 9007-12-9 (Calcitonin)
RN  - K7Q1JQR04M (Dinoprostone)
RN  - Q40Q9N063P (Acetic Acid)
SB  - IM
MH  - Acetates/antagonists & inhibitors
MH  - Acetic Acid
MH  - Adrenocorticotropic Hormone/*blood
MH  - Analgesics/*pharmacology
MH  - Animals
MH  - Calcitonin/*pharmacology
MH  - Dinoprostone/*blood
MH  - Male
MH  - Mice
MH  - Pain/chemically induced/prevention & control
MH  - Radioimmunoassay
MH  - beta-Endorphin/*blood
EDAT- 1994/01/01 00:00
MHDA- 1994/01/01 00:01
CRDT- 1994/01/01 00:00
PHST- 1994/01/01 00:00 [pubmed]
PHST- 1994/01/01 00:01 [medline]
PHST- 1994/01/01 00:00 [entrez]
PST - ppublish
SO  - Res Commun Chem Pathol Pharmacol. 1994 Jan;83(1):15-24.