PMID- 8165564
OWN - NLM
STAT- MEDLINE
DCOM- 19940520
LR  - 20211203
IS  - 0081-1386 (Print)
IS  - 0081-1386 (Linking)
VI  - 47
DP  - 1993
TI  - Hepatocyte growth factor/scatter factor (HGF/SF), the c-met receptor and the 
      behaviour of epithelial cells.
PG  - 163-81
AB  - Hepatocyte growth factor/scatter factor (HGF/SF) is a multifunctional protein 
      produced by fibroblasts and other mesenchymal cells and active on epithelial and 
      endothelial cells. The factor shares the basic domain organization of plasminogen 
      and other blood proteases and is produced as a single-chain high molecular weight 
      precursor which is subsequently cleaved to produce a biologically active 
      heterodimer. HGF/SF acts on target cells through binding to a cell surface, 
      high-affinity receptor with tyrosine kinase activity encoded by the c-met 
      proto-oncogene. Transduction of the HGF/SF signal in epithelial cells by the met 
      receptor leads either to: (i) cell dissociation, with loss of adhesion and 
      junctional communication, (ii) cell division or (iii) differentiation and 
      morphogenesis. These responses depend on target cells and culture conditions. 
      There is preliminary evidence for a role for HGF/SF in vivo, suggesting that the 
      factor may be involved in the early stages of embryo development and in liver 
      regeneration. A role in cancer growth or dissemination has been proposed but 
      remains to be clarified.
FAU - Gherardi, E
AU  - Gherardi E
AD  - ICRF Cell Interactions Laboratory, Cambridge University Medical School, UK.
FAU - Sharpe, M
AU  - Sharpe M
FAU - Lane, K
AU  - Lane K
FAU - Sirulnik, A
AU  - Sirulnik A
FAU - Stoker, M
AU  - Stoker M
LA  - eng
PT  - Journal Article
PT  - Review
PL  - England
TA  - Symp Soc Exp Biol
JT  - Symposia of the Society for Experimental Biology
JID - 0404517
RN  - 0 (MAS1 protein, human)
RN  - 0 (Proto-Oncogene Mas)
RN  - 67256-21-7 (Hepatocyte Growth Factor)
RN  - EC 2.7.10.1 (Proto-Oncogene Proteins c-met)
RN  - EC 2.7.10.1 (Receptor Protein-Tyrosine Kinases)
SB  - IM
MH  - Animals
MH  - Cell Differentiation/physiology
MH  - Cell Division/physiology
MH  - Cell Movement/physiology
MH  - Epithelial Cells
MH  - Hepatocyte Growth Factor/*metabolism
MH  - Humans
MH  - Liver/cytology/embryology/*metabolism
MH  - Mice
MH  - Morphogenesis/physiology
MH  - Proto-Oncogene Mas
MH  - Proto-Oncogene Proteins c-met
MH  - Receptor Protein-Tyrosine Kinases/*metabolism
RF  - 84
EDAT- 1993/01/01 00:00
MHDA- 1993/01/01 00:01
CRDT- 1993/01/01 00:00
PHST- 1993/01/01 00:00 [pubmed]
PHST- 1993/01/01 00:01 [medline]
PHST- 1993/01/01 00:00 [entrez]
PST - ppublish
SO  - Symp Soc Exp Biol. 1993;47:163-81.