PMID- 8167431
OWN - NLM
STAT- MEDLINE
DCOM- 19940602
LR  - 20191023
IS  - 0934-8840 (Print)
IS  - 0934-8840 (Linking)
VI  - 280
IP  - 3
DP  - 1994 Jan
TI  - Toxic shock syndrome toxin-1 (TSST-1) production and phage susceptibility of 
      Staphylococcus aureus strains from human vaginas and anterior nares in Trinidad.
PG  - 371-81
AB  - The carriage rates of Staphylococcus aureus in the anterior nares of children and 
      women as well as in the vagina of women were determined. The ability of strains 
      of S. aureus to produce toxic shock syndrome toxin-1 (TSST-1) and their 
      susceptibility to phages of the international phage set (IPS) for human strains 
      were also investigated. Of 200 women studied, the carriage rate of S. aureus in 
      high vaginal swabs and anterior nares swabs was 57 (28.5%) and 73 (36.5%), 
      respectively. Eight (4.0%) and 16 (8.0%) patients were carriers of 
      TSST-1-producing strains in their vaginas and anterior nares, respectively. 
      Amongst the 220 children sampled, 100 (45.5%) were carriers of S. aureus in their 
      anterior nares, with 51 (23.2%) children being positive for TSST-1 producing 
      strains. Overall, of the 233 strains of S. aureus isolated from all sources 176 
      (75.5%) were typable and 75 (32.2%) were positive for TSST-1 production. For 
      strains from anterior nares, isolates from children were more susceptible (81.2%) 
      to IPS phages than those from women (67.1%) but the difference was not 
      significant (P > or = 0.05; chi 2). Forty-five (76.3%) of 59 strains of vaginal 
      origin were typable. The frequency of production of TSST-1 amongst strains 
      isolated from children, i.e. (50.5% (51 of 101), was significantly higher (P > or 
      = 0.001; chi 2) than that found for isolates from women's anterior nares (21.9%) 
      and vagina (13.6%). S. aureus was recovered from both the anterior nares and 
      vaginal swabs of 11 patients sampled. The phage patterns of 5 of the 6 typable 
      pairs of isolates established their relatedness suggesting that the same strains 
      colonized the anterior nares and vagina of each of these patients. It was 
      concluded that the carriage of TSST-1-producing strains of S. aureus in the 
      anterior nares and vagina of women was much lower than that detected in 
      children's anterior nares and that the risk of vaginal toxic shock syndrome (TSS) 
      in Trinidadian women was relatively low. Susceptibility of strains was high to 
      IPS phages. Epidemiological significance was attributed to the finding that the 
      same strains of S. aureus colonized the anterior nares and vaginas of some women.
FAU - Adesiyun, A A
AU  - Adesiyun AA
AD  - School of Veterinary Medicine, Faculty of Medical Sciences, University of the 
      West Indies, St. Augustine, Trinidad.
FAU - Singh, D
AU  - Singh D
FAU - Gunness, R I
AU  - Gunness RI
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Germany
TA  - Zentralbl Bakteriol
JT  - Zentralblatt fur Bakteriologie : international journal of medical microbiology
JID - 9203851
RN  - 0 (Bacterial Toxins)
RN  - 0 (Enterotoxins)
RN  - 0 (Superantigens)
RN  - 0 (enterotoxin F, Staphylococcal)
SB  - IM
MH  - *Bacterial Toxins
MH  - Bacteriophage Typing
MH  - Carrier State/*epidemiology
MH  - Child
MH  - Enterotoxins/*isolation & purification
MH  - Female
MH  - Humans
MH  - Nasal Cavity/*microbiology
MH  - Staphylococcal Infections/*epidemiology/microbiology
MH  - Staphylococcus aureus/classification/isolation & purification
MH  - *Superantigens
MH  - Trinidad and Tobago/epidemiology
MH  - Vagina/*microbiology
EDAT- 1994/01/01 00:00
MHDA- 2000/05/11 09:00
CRDT- 1994/01/01 00:00
PHST- 1994/01/01 00:00 [pubmed]
PHST- 2000/05/11 09:00 [medline]
PHST- 1994/01/01 00:00 [entrez]
AID - 10.1016/s0934-8840(11)80599-2 [doi]
PST - ppublish
SO  - Zentralbl Bakteriol. 1994 Jan;280(3):371-81. doi: 10.1016/s0934-8840(11)80599-2.