PMID- 8169397
OWN - NLM
STAT- MEDLINE
DCOM- 19940602
LR  - 20190512
IS  - 0022-1899 (Print)
IS  - 0022-1899 (Linking)
VI  - 169
IP  - 5
DP  - 1994 May
TI  - The role of tumor necrosis factor-alpha in acute murine cytomegalovirus infection 
      in BALB/c mice.
PG  - 1088-91
AB  - The role of tumor necrosis factor-alpha (TNF alpha) in acute lethal and sublethal 
      murine cytomegalovirus (MCMV) infection in BALB/c mice was examined. During the 
      course of acute infection, TNF alpha was not detectable in the serum or 
      bronchoalveolar lavage (BAL) fluids, while TNF alpha was uniformly detected in 
      both serum and BAL following intravenous administration of lipopolysaccharide 
      (LPS). Administration of recombinant murine (rMu) TNF alpha did not consistently 
      alter the virus content of tissues during acute infection. Passive transfer of 
      purified polyclonal immunoglobulin containing neutralizing antibody to TNF alpha 
      did not alter mortality or MCMV replication in tissues during acute infection but 
      did block the TNF alpha response when LPS was administered to BALB/c mice. Thus, 
      TNF alpha appears to play little role in the course and outcome of acute MCMV 
      infection.
FAU - Shanley, J D
AU  - Shanley JD
AD  - Department of Medicine, University of Connecticut Health Center, Farmington, 
      Connecticut 06030.
FAU - Goff, E
AU  - Goff E
FAU - Debs, R J
AU  - Debs RJ
FAU - Forman, S J
AU  - Forman SJ
LA  - eng
GR  - AI-34813/AI/NIAID NIH HHS/United States
GR  - CA-30206/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - J Infect Dis
JT  - The Journal of infectious diseases
JID - 0413675
RN  - 0 (Recombinant Proteins)
RN  - 0 (Tumor Necrosis Factor-alpha)
SB  - IM
MH  - Acute Disease
MH  - Animals
MH  - Cells, Cultured
MH  - Cytomegalovirus/physiology
MH  - Cytomegalovirus Infections/*immunology
MH  - Female
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - Recombinant Proteins/administration & dosage
MH  - Tumor Necrosis Factor-alpha/administration & dosage/*physiology
MH  - Virus Replication
EDAT- 1994/05/01 00:00
MHDA- 1994/05/01 00:01
CRDT- 1994/05/01 00:00
PHST- 1994/05/01 00:00 [pubmed]
PHST- 1994/05/01 00:01 [medline]
PHST- 1994/05/01 00:00 [entrez]
AID - 10.1093/infdis/169.5.1088 [doi]
PST - ppublish
SO  - J Infect Dis. 1994 May;169(5):1088-91. doi: 10.1093/infdis/169.5.1088.