PMID- 8169428
OWN - NLM
STAT- MEDLINE
DCOM- 19940602
LR  - 20190512
IS  - 0022-1899 (Print)
IS  - 0022-1899 (Linking)
VI  - 169
IP  - 5
DP  - 1994 May
TI  - Elevated levels of tumor necrosis factor-alpha in Zairian neonate plasmas: 
      implications for perinatal infection with the human immunodeficiency virus.
PG  - 975-80
AB  - Plasma levels of tumor necrosis factor-alpha (TNF alpha) and the ability of 
      plasmas to induce HIV expression in chronically infected cell lines were measured 
      in samples from adults, cord blood, and neonates from Zaire and North America. 
      Plasma levels of TNF alpha were higher in Zairian neonates born to HIV-negative 
      and -positive mothers than in uninfected Zairian adults (612 vs. 128 vs. 8 pg/mL, 
      P < .001); this dichotomy persisted until children were 9 months old. Plasmas 
      from neonates of HIV-negative Zairian mothers also stimulated higher levels of 
      reverse transcriptase from HIV-infected cell lines than did plasma from 
      HIV-negative Zairian adults (1339 vs. 110 cpm, P < .001). Similar patterns were 
      noted in plasmas from HIV-negative North American adults and neonates; however, 
      TNF alpha levels were markedly lower, and smaller differences were noted among 
      North American adults and neonates than those in the Zairian cohort. Markedly 
      elevated plasma TNF alpha levels in Zairian neonates and infants may play a role 
      in the pathogenesis and progression of HIV disease in this patient population.
FAU - Brown, C C
AU  - Brown CC
AD  - Laboratory of Immunoregulation, National Institute of Allergy and Infectious 
      Diseases, National Institutes of Health, Bethesda, Maryland 29892.
FAU - Poli, G
AU  - Poli G
FAU - Lubaki, N
AU  - Lubaki N
FAU - St Louis, M
AU  - St Louis M
FAU - Davachi, F
AU  - Davachi F
FAU - Musey, L
AU  - Musey L
FAU - Manzila, T
AU  - Manzila T
FAU - Kovacs, A
AU  - Kovacs A
FAU - Quinn, T C
AU  - Quinn TC
FAU - Fauci, A S
AU  - Fauci AS
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Infect Dis
JT  - The Journal of infectious diseases
JID - 0413675
RN  - 0 (Tumor Necrosis Factor-alpha)
SB  - IM
MH  - Adult
MH  - Cell Line
MH  - Democratic Republic of the Congo
MH  - Female
MH  - HIV Infections/*blood/physiopathology
MH  - *HIV-1/physiology
MH  - Humans
MH  - Infant, Newborn
MH  - Pregnancy
MH  - Pregnancy Complications, Infectious/blood/physiopathology
MH  - Tumor Necrosis Factor-alpha/*analysis
MH  - Up-Regulation
MH  - Virus Replication
EDAT- 1994/05/01 00:00
MHDA- 1994/05/01 00:01
CRDT- 1994/05/01 00:00
PHST- 1994/05/01 00:00 [pubmed]
PHST- 1994/05/01 00:01 [medline]
PHST- 1994/05/01 00:00 [entrez]
AID - 10.1093/infdis/169.5.975 [doi]
PST - ppublish
SO  - J Infect Dis. 1994 May;169(5):975-80. doi: 10.1093/infdis/169.5.975.