PMID- 8170345
OWN - NLM
STAT- MEDLINE
DCOM- 19940601
LR  - 20190825
IS  - 0169-328X (Print)
IS  - 0169-328X (Linking)
VI  - 21
IP  - 3-4
DP  - 1994 Feb
TI  - Distinctive four promoters collectively direct expression of brain-derived 
      neurotrophic factor gene.
PG  - 206-18
AB  - In order to get a deeper insight into comprehensive understanding of gene 
      regulation of brain-derived neurotrophic factor (BDNF), we characterized the 
      transcriptional apparatus of this gene on the basis of the genomic structure. The 
      results in this study revealed that there are at least four distinctive promoters 
      in the BDNF gene; two of them are neuron-specific and the rest are active in some 
      non-neuronal tissues as well as neuronal ones. Although the analyses of the 
      promoter usage pattern clarified many characteristic features in controlling 
      these promoter activities, the most notable finding was that administration of 
      kainic acid resulted in great activation of two out of the four promoters in 
      hippocampal neurons in a regionally different manner and thus indicated the 
      presence of two distinct signal transduction pathways for kainate-induced 
      activation of BDNF gene expression in neurons. The analysis of BDNF gene 
      expression in terms of the promoter usage pattern would provide a new and 
      important insight into understanding a molecular control mechanism of this gene 
      expression.
FAU - Nakayama, M
AU  - Nakayama M
AD  - Shionogi Research Laboratories, Shionogi & Co., Ltd., Osaka, Japan.
FAU - Gahara, Y
AU  - Gahara Y
FAU - Kitamura, T
AU  - Kitamura T
FAU - Ohara, O
AU  - Ohara O
LA  - eng
SI  - GENBANK/S71196
SI  - GENBANK/S71201
SI  - GENBANK/S71209
SI  - GENBANK/S71211
PT  - Journal Article
PL  - Netherlands
TA  - Brain Res Mol Brain Res
JT  - Brain research. Molecular brain research
JID - 8908640
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Nerve Growth Factors)
RN  - 0 (Nerve Tissue Proteins)
RN  - 0 (RNA, Messenger)
SB  - IM
MH  - Animals
MH  - Base Sequence
MH  - Brain/metabolism
MH  - Brain-Derived Neurotrophic Factor
MH  - *Exons
MH  - Gene Expression
MH  - *Genome
MH  - Hippocampus/metabolism
MH  - In Situ Hybridization
MH  - Male
MH  - Molecular Sequence Data
MH  - Nerve Growth Factors/*genetics
MH  - Nerve Tissue Proteins/*genetics
MH  - Neurons/metabolism
MH  - *Promoter Regions, Genetic
MH  - RNA, Messenger/analysis
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Seizures/metabolism
EDAT- 1994/02/01 00:00
MHDA- 1994/02/01 00:01
CRDT- 1994/02/01 00:00
PHST- 1994/02/01 00:00 [pubmed]
PHST- 1994/02/01 00:01 [medline]
PHST- 1994/02/01 00:00 [entrez]
AID - 0169-328X(94)90251-8 [pii]
AID - 10.1016/0169-328x(94)90251-8 [doi]
PST - ppublish
SO  - Brain Res Mol Brain Res. 1994 Feb;21(3-4):206-18. doi: 
      10.1016/0169-328x(94)90251-8.