PMID- 8171416
OWN - NLM
STAT- MEDLINE
DCOM- 19940527
LR  - 20190727
IS  - 0049-3848 (Print)
IS  - 0049-3848 (Linking)
VI  - 73
IP  - 2
DP  - 1994 Jan 15
TI  - Neutralization of the anticoagulant activity of low molecular weight heparin LU 
      47311 (Clivarin) in man by protamine chloride.
PG  - 85-93
AB  - Bleeding induced by unfractionated heparin (UFH) can be antagonized by protamine 
      as shown by normalization of thrombin time and aPTT. In order to learn about the 
      neutralization capacity of protamine against the anticoagulant effects of LU 
      47311 a comparison study vs UFH was performed in 12 healthy male volunteers. 
      Whereas the prolongation of aPTT and thrombin time induced by both heparins was 
      reversed, inhibition of anti F Xa activity was not. A anti F Xa activity 
      following injection of UFH was immediately antagonized by only 20-40% with LU 
      47311. A rebound phenomenon of LU 47311 after protamine chloride was not 
      detected. The platelet system remained unchanged.
FAU - Andrassy, K
AU  - Andrassy K
AD  - Department of Medicine, University Hospital, Heidelberg, Germany.
FAU - Eschenfelder, V
AU  - Eschenfelder V
FAU - Weber, E
AU  - Weber E
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Thromb Res
JT  - Thrombosis research
JID - 0326377
RN  - 0 (Anticoagulants)
RN  - 0 (Factor Xa Inhibitors)
RN  - 0 (Heparin Antagonists)
RN  - 0 (Heparin, Low-Molecular-Weight)
RN  - 0 (Protamines)
RN  - 5R0L1D739E (reviparin)
SB  - IM
MH  - Adult
MH  - Anticoagulants/*antagonists & inhibitors
MH  - Blood Coagulation/*drug effects
MH  - Factor Xa Inhibitors
MH  - *Heparin Antagonists
MH  - Heparin, Low-Molecular-Weight/*pharmacology
MH  - Humans
MH  - Male
MH  - Partial Thromboplastin Time
MH  - Protamines/*pharmacology
MH  - Prothrombin Time
MH  - Thrombin Time
EDAT- 1994/01/15 00:00
MHDA- 1994/01/15 00:01
CRDT- 1994/01/15 00:00
PHST- 1994/01/15 00:00 [pubmed]
PHST- 1994/01/15 00:01 [medline]
PHST- 1994/01/15 00:00 [entrez]
AID - 10.1016/0049-3848(94)90083-3 [doi]
PST - ppublish
SO  - Thromb Res. 1994 Jan 15;73(2):85-93. doi: 10.1016/0049-3848(94)90083-3.