PMID- 8172817
OWN - NLM
STAT- MEDLINE
DCOM- 19940609
LR  - 20190512
IS  - 0923-7534 (Print)
IS  - 0923-7534 (Linking)
VI  - 5 Suppl 1
DP  - 1994
TI  - Investigation of the activation state of the X chromosome in non-Hodgkin's 
      lymphomas.
PG  - 47-50
AB  - Cytogenetic analysis of non-Hodgkin's lymphomas (NHLs) has previously revealed a 
      high incidence of numerical abnormalities involving the X chromosome. We have now 
      used a combination of fluorescence in situ hybridization (FISH) and Southern blot 
      analysis of methylation to examine the activation state of additional X 
      chromosomes in NHL. Although FISH analysis of X chromosome centromeres in 
      interphase nuclei was complicated by a number of factors, such as cell-cycle 
      position, there was evidence that more than one X chromosome was present in the 
      active state in 4/9 NHL. Methylation studies were carried out using the M27 beta 
      probe, which also suggested that more than one activated X chromosome was present 
      in at least 2/7 NHL cases. The two approaches therefore provided evidence that in 
      some cases of NHL, unlike sex-chromosome-syndrome individuals, additional X 
      chromosomes may be present in the active state. These data support the suggestion 
      that NHL-associated oncogenes might be located on the X chromosome.
FAU - Grierson, A J
AU  - Grierson AJ
AD  - Department of Clinical Oncology, University Medical School, Sheffield, UK.
FAU - Hammond, D W
AU  - Hammond DW
FAU - Goepel, J R
AU  - Goepel JR
FAU - Hancock, B W
AU  - Hancock BW
FAU - Goyns, M H
AU  - Goyns MH
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Ann Oncol
JT  - Annals of oncology : official journal of the European Society for Medical 
      Oncology
JID - 9007735
SB  - IM
MH  - Blotting, Southern
MH  - Chromosome Mapping
MH  - Gene Expression
MH  - Heterozygote
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Lymphoma, Non-Hodgkin/*genetics
MH  - Methylation
MH  - Sex Chromosome Aberrations/etiology
MH  - *X Chromosome
EDAT- 1994/01/01 00:00
MHDA- 1994/01/01 00:01
CRDT- 1994/01/01 00:00
PHST- 1994/01/01 00:00 [pubmed]
PHST- 1994/01/01 00:01 [medline]
PHST- 1994/01/01 00:00 [entrez]
AID - 10.1093/annonc/5.suppl_1.s47 [doi]
PST - ppublish
SO  - Ann Oncol. 1994;5 Suppl 1:47-50. doi: 10.1093/annonc/5.suppl_1.s47.