PMID- 8172818
OWN - NLM
STAT- MEDLINE
DCOM- 19940609
LR  - 20190512
IS  - 0923-7534 (Print)
IS  - 0923-7534 (Linking)
VI  - 5 Suppl 1
DP  - 1994
TI  - Chromosome analysis of non-Hodgkin's lymphomas by fluorescence in situ 
      hybridization.
PG  - 51-4
AB  - We have recently carried out a cytogenetic survey of a series of non-Hodgkin's 
      lymphomas (NHLs) and identified chromosomal abnormalities in most of the samples 
      studied. A third of these cases, however, had to be recorded as containing 
      derivative or marker chromosomes, whose origins were either partially or 
      completely unknown. In an attempt to further analyse such cases, we have adopted 
      the fluorescence in situ hybridization (FISH) technique. The FISH technique has 
      allowed us to map the myb gene to 6q23, and then to study its position on 6q- 
      derivative chromosomes in the NHL cells. The related FISH technique of chromosome 
      painting has enabled us to identify a marker chromosome in one of our cases as an 
      abnormal X chromosome, and in other cases has allowed 14q+ derivative chromosomes 
      to be further analysed. We have also applied the FISH technique to the analysis 
      of interphase nuclei, and have been able to determine numerical chromosome 
      changes in NHL interphase cells. The application of the FISH technique to the 
      study of NHL cell chromosomes is likely to enable the identification of most 
      chromosomal abnormalities present, and so may reveal the critical events leading 
      to malignant transformation of lymphoid cells.
FAU - Hammond, D W
AU  - Hammond DW
AD  - Department of Clinical Oncology, University Medical School, Sheffield, UK.
FAU - Hancock, B W
AU  - Hancock BW
FAU - Goyns, M H
AU  - Goyns MH
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Ann Oncol
JT  - Annals of oncology : official journal of the European Society for Medical 
      Oncology
JID - 9007735
RN  - 0 (Genetic Markers)
SB  - IM
GS  - myb
MH  - Biopsy
MH  - Chromosome Aberrations/*etiology
MH  - Chromosome Disorders
MH  - Chromosomes, Human, Pair 14
MH  - Chromosomes, Human, Pair 18
MH  - Genetic Markers
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Lymphoma, Non-Hodgkin/*genetics/pathology
MH  - Translocation, Genetic
MH  - Tumor Cells, Cultured
EDAT- 1994/01/01 00:00
MHDA- 1994/01/01 00:01
CRDT- 1994/01/01 00:00
PHST- 1994/01/01 00:00 [pubmed]
PHST- 1994/01/01 00:01 [medline]
PHST- 1994/01/01 00:00 [entrez]
AID - 10.1093/annonc/5.suppl_1.s51 [doi]
PST - ppublish
SO  - Ann Oncol. 1994;5 Suppl 1:51-4. doi: 10.1093/annonc/5.suppl_1.s51.