PMID- 8172988
OWN - NLM
STAT- MEDLINE
DCOM- 19940606
LR  - 20190914
IS  - 1044-3983 (Print)
IS  - 1044-3983 (Linking)
VI  - 5
IP  - 2
DP  - 1994 Mar
TI  - Aspirin use and lung, colon, and breast cancer incidence in a prospective study.
PG  - 138-46
AB  - A large body of experimental data and several recent epidemiologic studies 
      indicate that aspirin use may decrease cancer risk. The experimental studies 
      found effects at many anatomic sites, whereas the epidemiologic studies saw the 
      greatest effect on mortality from digestive cancers. To provide further human 
      data, we examined the association between aspirin use and cancer risk using data 
      from the National Health and Nutrition Examination Survey I (NHANES I) and the 
      NHANES I Epidemiologic Follow-up Studies (NHEFS). Characterization of aspirin use 
      was based on questions in the baseline interview asking whether subjects used 
      aspirin during the previous 30 days. Data were available from 12,668 subjects age 
      25-74, at time of initial examination for NHANES I, who were followed for an 
      average of 12.4 years. Among these subjects, 1,257 were diagnosed with cancer 
      more than 2 years after their NHANES I examination. Incidence of several cancers 
      was lower among persons who reported aspirin use: the incidence rate ratios (and 
      95% confidence intervals) for all sites combined were 0.83 (0.74-0.93), lung 
      cancer 0.68 (0.49-0.94), breast cancer in women 0.70 (0.50-0.96), and colorectal 
      cancer in younger men 0.35 (0.17-0.73). These findings were not readily explained 
      by potentially confounding factors. The data suggest an association between 
      aspirin consumption and decreased cancer incidence at several cancer sites.
FAU - Schreinemachers, D M
AU  - Schreinemachers DM
AD  - Health Effects Research Laboratory, U.S. Environmental Protection Agency, 
      Research Triangle Park, NC 27711.
FAU - Everson, R B
AU  - Everson RB
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Epidemiology
JT  - Epidemiology (Cambridge, Mass.)
JID - 9009644
RN  - R16CO5Y76E (Aspirin)
SB  - IM
CIN - Epidemiology. 1994 Mar;5(2):133-5. PMID: 8172986
MH  - Adult
MH  - Aged
MH  - Aspirin/*therapeutic use
MH  - Breast Neoplasms/*epidemiology/prevention & control
MH  - Cohort Studies
MH  - Colorectal Neoplasms/*epidemiology/prevention & control
MH  - Confidence Intervals
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Incidence
MH  - Lung Neoplasms/*epidemiology/prevention & control
MH  - Male
MH  - Middle Aged
MH  - Pharmacoepidemiology
MH  - Prospective Studies
MH  - Risk Factors
MH  - United States/epidemiology
EDAT- 1994/03/01 00:00
MHDA- 1994/03/01 00:01
CRDT- 1994/03/01 00:00
PHST- 1994/03/01 00:00 [pubmed]
PHST- 1994/03/01 00:01 [medline]
PHST- 1994/03/01 00:00 [entrez]
AID - 10.1097/00001648-199403000-00003 [doi]
PST - ppublish
SO  - Epidemiology. 1994 Mar;5(2):138-46. doi: 10.1097/00001648-199403000-00003.