PMID- 8173039 OWN - NLM STAT- MEDLINE DCOM- 19940606 LR - 20191023 IS - 0006-355X (Print) IS - 0006-355X (Linking) VI - 31 IP - 1 DP - 1994 Jan-Feb TI - Rheologic and hemodynamic characteristics of red cells of mouse, rat and human. PG - 103-13 AB - The present study compares hematologic, rheologic and hemodynamic characteristics of red cells from mouse, rat and human. Red cells in these species are biconcave discs that show significant differences in diameter and mean corpuscular volume (MCV). However, differences in mean corpuscular hemoglobin concentration (MCHC) are not significant. Viscosity measurement of washed red cell suspensions (in each case the medium osmolarity adjusted to match plasma osmolarity) showed significant interspecies differences at shear rates of 37.5 and 750 sec-1 as follows: Human > rat > mouse. Hemodynamic and microcirculatory behavior of these red cells was investigated in the artificially perfused ex vivo mesocecum vasculature of the rat. Hemodynamic measurements in the whole ex vivo mesocecum preparation revealed maximal increase in the peripheral resistance unit (PRU) for the human red cells followed by the rat and mouse red cells, respectively at a hematocrit (Hct) of 40%. Further, measurements of red cell velocities (Vrbc) in single arterioles of the mesocecum vasculature, during sustained perfusion with washed red cell suspensions, showed that at any given perfusion pressure (Pa), Vrbc for both mouse and rat red cells was higher than that for human red cells, while Vrbc for mouse red cells was higher than that for the rat. These results demonstrate that the microvascular flow behavior of these red cells is likely to be influenced by both physical and rheologic characteristics. FAU - Chen, D AU - Chen D AD - Department of Medicine, Albert Einstein College of Medicine, Bronx, NY 10461. FAU - Kaul, D K AU - Kaul DK LA - eng GR - HL 45931/HL/NHLBI NIH HHS/United States PT - Comparative Study PT - Journal Article PT - Research Support, Non-U.S. Gov't PT - Research Support, U.S. Gov't, P.H.S. PL - Netherlands TA - Biorheology JT - Biorheology JID - 0372526 SB - IM MH - Animals MH - Blood Flow Velocity MH - Blood Viscosity MH - Culture Techniques MH - Erythrocytes/*physiology/ultrastructure MH - *Hemodynamics MH - *Hemorheology MH - Humans MH - Mice/*physiology MH - Rats/*physiology MH - Rats, Wistar MH - Species Specificity MH - Vascular Resistance EDAT- 1994/01/01 00:00 MHDA- 1994/01/01 00:01 CRDT- 1994/01/01 00:00 PHST- 1994/01/01 00:00 [pubmed] PHST- 1994/01/01 00:01 [medline] PHST- 1994/01/01 00:00 [entrez] AID - 10.3233/bir-1994-31109 [doi] PST - ppublish SO - Biorheology. 1994 Jan-Feb;31(1):103-13. doi: 10.3233/bir-1994-31109.