PMID- 8173343
OWN - NLM
STAT- MEDLINE
DCOM- 19940606
LR  - 20131121
IS  - 1053-4245 (Print)
IS  - 1053-4245 (Linking)
VI  - 3
IP  - 4
DP  - 1993 Oct-Dec
TI  - Biological indicators for monitoring exposure/toxicity from III-V semiconductors.
PG  - 431-40
AB  - These studies were conducted to assess alterations in renal tubule cell gene 
      expression following in vivo exposure to the semiconductor elements indium (In), 
      arsenic (As) or indium arsenide (InAs). Alterations in proximal tubule cell gene 
      expression were monitored at similar tissue concentrations of In or As at various 
      time-points following single subcutaneous (sc) injections of In, As or InAs at 0, 
      10 and 30 days (In: 1.5 mg/kg; As, 3 mg/kg or 0.3 mg/k; and InAs: 1000 mg/kg). 
      Protein synthesis as monitored by incorporation of 35S methionine was not 
      statistically increased over the 30-day period following sc injection of As, In 
      or InAs relative to controls. Two dimensional--SDS/polyacrylamide gel 
      electrophoresis showed that exposure to InAs stimulated the synthesis of a number 
      of proteins with molecular masses of < 10, 18, 28, 32, 38, 42, 58, 70, 98 KDa. 
      Exposure to As produced an increase in the expression of thirteen gene products. 
      Indium produced similar changes at the 10-day time-point, but increased tissue 
      accumulation of this element at 30 days markedly suppressed the stress protein 
      response. These data indicate that induction of these specific gene expression 
      patterns may be useful as early indicators for assessing exposure to InAs, or 
      inorganic As, while suppression of these responses by In suggests a compromise in 
      this basic protective mechanism.
FAU - Conner, E A
AU  - Conner EA
AD  - University of Maryland, Graduate School Baltimore 21227.
FAU - Yamauchi, H
AU  - Yamauchi H
FAU - Fowler, B A
AU  - Fowler BA
FAU - Akkerman, M
AU  - Akkerman M
LA  - eng
GR  - R01-ESO-4979-02/ES/NIEHS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - England
TA  - J Expo Anal Environ Epidemiol
JT  - Journal of exposure analysis and environmental epidemiology
JID - 9111438
RN  - 0 (Proteins)
RN  - 045A6V3VFX (Indium)
RN  - N712M78A8G (Arsenic)
SB  - IM
MH  - Animals
MH  - Arsenic/administration & dosage/*adverse effects
MH  - Cricetinae
MH  - Indium/administration & dosage/*adverse effects
MH  - Kidney Tubules, Proximal/drug effects/*metabolism
MH  - Male
MH  - Mesocricetus
MH  - Occupational Exposure
MH  - Proteins/drug effects/*metabolism
MH  - Semiconductors
EDAT- 1993/10/01 00:00
MHDA- 1993/10/01 00:01
CRDT- 1993/10/01 00:00
PHST- 1993/10/01 00:00 [pubmed]
PHST- 1993/10/01 00:01 [medline]
PHST- 1993/10/01 00:00 [entrez]
PST - ppublish
SO  - J Expo Anal Environ Epidemiol. 1993 Oct-Dec;3(4):431-40.