PMID- 8173709
OWN - NLM
STAT- MEDLINE
DCOM- 19940606
LR  - 20191023
IS  - 0954-6928 (Print)
IS  - 0954-6928 (Linking)
VI  - 4
IP  - 11
DP  - 1993 Nov
TI  - Serum immunoglobulin E and sudden cardiac arrest during myocardial infarction.
PG  - 1029-32
AB  - BACKGROUND: While studying the immunological response to acute myocardial 
      infarction (AMI) we noticed that patients who on admission had a high serum 
      immunoglobulin E (IgE) level were less likely to die suddenly. This observation 
      seemed to deserve verification since atopic patients whose production of IgE was 
      excessive had been reported to have depressed haemostatic platelet function and 
      impaired thrombinogenesis. METHODS: We measured levels of serum IgE in 386 
      patients with AMI at the time of admission to the coronary care unit. Patients 
      were divided into two groups, depending on the presence (n = 55) or absence (n = 
      331) of sudden cardiac arrest. The two groups did not differ with respect to age, 
      sex, or risk factors for coronary artery disease. RESULTS: The mean level of 
      serum IgE was significantly higher in the group without sudden cardiac arrest 
      than in the group with this complication. In a separate study we found that high 
      serum IgE levels were associated with delayed thrombin generation in the clotting 
      blood of survivors of myocardial infarction. CONCLUSION: Early determination of 
      serum IgE levels might help to detect patients at risk of sudden cardiac arrest 
      during myocardial infarction. Patients with high serum IgE levels might be 
      protected against sudden cardiac death through the depression of clot formation 
      because of the late appearance of thrombin in their coronary arteries.
FAU - Szczeklik, A
AU  - Szczeklik A
AD  - Department of Medicine, Jagellonian University, Cracow, Poland.
FAU - Dropinski, J
AU  - Dropinski J
FAU - Gora, P F
AU  - Gora PF
LA  - eng
PT  - Journal Article
PL  - England
TA  - Coron Artery Dis
JT  - Coronary artery disease
JID - 9011445
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Aged
MH  - Female
MH  - Heart Arrest/*blood/complications
MH  - Humans
MH  - Immunoglobulin E/*blood
MH  - Male
MH  - Middle Aged
MH  - Myocardial Infarction/*blood/complications
MH  - Risk Factors
EDAT- 1993/11/01 00:00
MHDA- 1993/11/01 00:01
CRDT- 1993/11/01 00:00
PHST- 1993/11/01 00:00 [pubmed]
PHST- 1993/11/01 00:01 [medline]
PHST- 1993/11/01 00:00 [entrez]
AID - 10.1097/00019501-199311000-00012 [doi]
PST - ppublish
SO  - Coron Artery Dis. 1993 Nov;4(11):1029-32. doi: 10.1097/00019501-199311000-00012.