PMID- 8174069
OWN - NLM
STAT- MEDLINE
DCOM- 19940609
LR  - 20190816
IS  - 0165-4608 (Print)
IS  - 0165-4608 (Linking)
VI  - 73
IP  - 1
DP  - 1994 Mar
TI  - Molecular characterization of a recurring complex chromosomal translocation in 
      two human extragonadal germ cell tumors.
PG  - 11-6
AB  - The molecular characterization of a recurring complex chromosomal translocation 
      involving 6p21, 6p22, 6q23, and 11q13 in two independent but similar extragonadal 
      human germ cell tumors was initiated using fluorescence in situ hybridization 
      (FISH) and pulse field gel electrophoresis (PFGE) techniques. By using a series 
      of specific probes from the 11q13 region, the translocation breakpoint in this 
      chromosomal band could be located within a long-range restriction enzyme map in 
      between the markers D11S457 and D11S546. In addition, aberrantly hybridizing 
      restriction fragments were revealed by PFGE in both tumors, indicating that the 
      breakpoint region must be located within a distance of at maximum 200 kilobase 
      pairs (kbp) from the nearest DNA marker (D11S546).
FAU - Sinke, R J
AU  - Sinke RJ
AD  - Department of Human Genetics, University Hospital, Nijmegen, The Netherlands.
FAU - Weghuis, D O
AU  - Weghuis DO
FAU - Suijkerbuijk, R F
AU  - Suijkerbuijk RF
FAU - Tanigami, A
AU  - Tanigami A
FAU - Nakamura, Y
AU  - Nakamura Y
FAU - Larsson, C
AU  - Larsson C
FAU - Weber, G
AU  - Weber G
FAU - de Jong, B
AU  - de Jong B
FAU - Oosterhuis, J W
AU  - Oosterhuis JW
FAU - Molenaar, W M
AU  - Molenaar WM
AU  - et al.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Cancer Genet Cytogenet
JT  - Cancer genetics and cytogenetics
JID - 7909240
RN  - 0 (DNA Probes)
RN  - 0 (Genetic Markers)
SB  - IM
MH  - Blotting, Southern
MH  - *Chromosomes, Human, Pair 11
MH  - *Chromosomes, Human, Pair 6
MH  - DNA Probes
MH  - Electrophoresis, Gel, Pulsed-Field
MH  - Genetic Markers
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Karyotyping
MH  - Mediastinal Neoplasms/*genetics
MH  - Retroperitoneal Neoplasms/*genetics
MH  - Teratoma/*genetics
MH  - *Translocation, Genetic
MH  - Tumor Cells, Cultured
EDAT- 1994/03/01 00:00
MHDA- 1994/03/01 00:01
CRDT- 1994/03/01 00:00
PHST- 1994/03/01 00:00 [pubmed]
PHST- 1994/03/01 00:01 [medline]
PHST- 1994/03/01 00:00 [entrez]
AID - 0165-4608(94)90176-7 [pii]
AID - 10.1016/0165-4608(94)90176-7 [doi]
PST - ppublish
SO  - Cancer Genet Cytogenet. 1994 Mar;73(1):11-6. doi: 10.1016/0165-4608(94)90176-7.