PMID- 8174070
OWN - NLM
STAT- MEDLINE
DCOM- 19940609
LR  - 20190816
IS  - 0165-4608 (Print)
IS  - 0165-4608 (Linking)
VI  - 73
IP  - 1
DP  - 1994 Mar
TI  - Demonstration of i(17q) in metaphase and interphase of malignant hematopoietic 
      cells by fluorescence in situ hybridization.
PG  - 17-22
AB  - In 10 patients with various hematopoietic disorders, i(17q) has been studied by 
      the technique of fluorescence in situ hybridization (FISH) both in metaphase and 
      interphase cells using an alpha-satellite centromere-specific probe #17. We 
      observed some minor quantitative differences between metaphase and interphase 
      cells with regard to the incidence of i(17q) in individual cases and considerable 
      heteromorphism of the size of signal of i(17q) among different cases. Our results 
      suggest that formation of i(17q) results from a break in the p-arm proximal to 
      the centromere and that the breakpoints vary from case to case.
FAU - Shi, G
AU  - Shi G
AD  - Department of Oncology/Hematology, Medical University Clinic, Hamburg, Germany.
FAU - Weh, H J
AU  - Weh HJ
FAU - Hossfeld, D K
AU  - Hossfeld DK
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Cancer Genet Cytogenet
JT  - Cancer genetics and cytogenetics
JID - 7909240
SB  - IM
CIN - Cancer Genet Cytogenet. 1995 Apr;80(2):170. PMID: 7736441
MH  - Aneuploidy
MH  - Blood Cells/pathology
MH  - Bone Marrow/*pathology
MH  - *Chromosome Aberrations
MH  - *Chromosomes, Human, Pair 17
MH  - Female
MH  - Hematopoietic Stem Cells/pathology
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Interphase
MH  - Leukemia/*genetics/pathology
MH  - Leukemia, Myelogenous, Chronic, BCR-ABL Positive/genetics/pathology
MH  - Leukemia, Myeloid, Acute/genetics/pathology
MH  - Leukemia, Myelomonocytic, Acute/genetics/pathology
MH  - Male
MH  - Metaphase
EDAT- 1994/03/01 00:00
MHDA- 1994/03/01 00:01
CRDT- 1994/03/01 00:00
PHST- 1994/03/01 00:00 [pubmed]
PHST- 1994/03/01 00:01 [medline]
PHST- 1994/03/01 00:00 [entrez]
AID - 0165-4608(94)90177-5 [pii]
AID - 10.1016/0165-4608(94)90177-5 [doi]
PST - ppublish
SO  - Cancer Genet Cytogenet. 1994 Mar;73(1):17-22. doi: 10.1016/0165-4608(94)90177-5.