PMID- 8174093
OWN - NLM
STAT- MEDLINE
DCOM- 19940609
LR  - 20190816
IS  - 0165-4608 (Print)
IS  - 0165-4608 (Linking)
VI  - 73
IP  - 2
DP  - 1994 Apr
TI  - Detection of bcl rearrangements in B-CLL by fluorescence in situ hybridization.
PG  - 165-8
AB  - Data concerning oncogene activation in CLL are very limited. When studied by 
      Southern blot, rearrangements of bcl-1, bcl-2, and bcl-3 have been only 
      infrequently reported. We evaluated the role of fluorescence in situ 
      hybridization (FISH) in the detection of gene rearrangements in two CLL patients. 
      We used multiple DNA probes, including those of chromosome 12, immunoglobulin 
      heavy and light chains, and the oncogenes bcl-1, bcl-2, and bcl-3. Additionally, 
      routine cytogenetic study was performed. In one patient, trisomy 12 and bcl-2 
      translocation were demonstrated by both methods, while trisomy 12 and bcl-1 
      translocation were seen in the second patient, who had a normal karyotype. Larger 
      studies should evaluate the role of FISH in the detection of oncogene involvement 
      in CLL and compare it with other molecular methods.
FAU - Amiel, A
AU  - Amiel A
AD  - Department of Medicine, Meir Hospital Kfar-Saba, Israel.
FAU - Lishner, M
AU  - Lishner M
FAU - Lalkin, A
AU  - Lalkin A
FAU - Gaber, E
AU  - Gaber E
FAU - Manor, Y
AU  - Manor Y
FAU - Fejgin, M
AU  - Fejgin M
FAU - Yarkoni, S
AU  - Yarkoni S
FAU - Ravid, M
AU  - Ravid M
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - United States
TA  - Cancer Genet Cytogenet
JT  - Cancer genetics and cytogenetics
JID - 7909240
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - *Chromosomes, Human, Pair 12
MH  - *Gene Rearrangement, B-Lymphocyte, Heavy Chain
MH  - *Gene Rearrangement, B-Lymphocyte, Light Chain
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Leukemia, Lymphocytic, Chronic, B-Cell/*genetics
MH  - Male
MH  - Middle Aged
MH  - *Translocation, Genetic
MH  - *Trisomy
EDAT- 1994/04/01 00:00
MHDA- 1994/04/01 00:01
CRDT- 1994/04/01 00:00
PHST- 1994/04/01 00:00 [pubmed]
PHST- 1994/04/01 00:01 [medline]
PHST- 1994/04/01 00:00 [entrez]
AID - 0165-4608(94)90203-8 [pii]
AID - 10.1016/0165-4608(94)90203-8 [doi]
PST - ppublish
SO  - Cancer Genet Cytogenet. 1994 Apr;73(2):165-8. doi: 10.1016/0165-4608(94)90203-8.