PMID- 8174322
OWN - NLM
STAT- MEDLINE
DCOM- 19940606
LR  - 20061115
IS  - 0009-918X (Print)
IS  - 0009-918X (Linking)
VI  - 33
IP  - 12
DP  - 1993 Dec
TI  - [Neurotrophins as a therapeutic tool for degenerative neuronal disorders].
PG  - 1265-9
AB  - Nerve growth factor (NGF) is the prototype of a family of structurally related 
      neurotrophic factors, named as neurotrophins, that also include brain-derived 
      neurotrophic factor (BDNF), neurotrophin (NT)-3, NT-4 and NT-5. NGF is known to 
      support the development and maintenance of sympathetic and neural crest-derived 
      sensory neurons in the peripheral nervous system (PNS). In the central nervous 
      system (CNS), NGF stimulates the survival of basal forebrain cholinergic neurons 
      both in vivo and vitro. BDNF supports the survival of much wider types of neurons 
      including nodose ganglion sensory neurons in the PNS, spinal motoneurons, basal 
      forebrain cholinergic neurons and mesencephalic dopaminergic neurons in the CNS 
      in culture. Pathophysiological observations and complementary animal experiments 
      suggest the possible use of neurotrophins as therapeutic tools for degenerative 
      neuronal disorders. However, applications of neurotrophins are macromolecules 
      that cannot pass through the blood-brain barrier. Also, it is not possible to 
      produce them in a large scale. In view of this, facilitatory measures to enhance 
      neurotrophin production by either pharmacological or medical means are possible 
      promising approaches in employing neurotrophin functions as a therapy. I 
      described here a successful result that pharmacological induction of NGF and BDNF 
      enhanced sprouting of nerve fibers from proximal site of transected rat sciatic 
      nerve.
FAU - Furukawa, S
AU  - Furukawa S
AD  - Department of Molecular Biology, Gifu Pharmaceutical University.
LA  - jpn
PT  - English Abstract
PT  - Journal Article
PT  - Review
PL  - Japan
TA  - Rinsho Shinkeigaku
JT  - Rinsho shinkeigaku = Clinical neurology
JID - 0417466
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Nerve Growth Factors)
RN  - 0 (Nerve Tissue Proteins)
SB  - IM
MH  - Amino Acid Sequence
MH  - Animals
MH  - Brain-Derived Neurotrophic Factor
MH  - Humans
MH  - Molecular Sequence Data
MH  - *Nerve Degeneration
MH  - Nerve Growth Factors/*physiology
MH  - Nerve Regeneration
MH  - Nerve Tissue Proteins/chemistry/*physiology
MH  - Nervous System Diseases/*therapy
MH  - Neurons/physiology
MH  - Rats
RF  - 10
EDAT- 1993/12/01 00:00
MHDA- 1993/12/01 00:01
CRDT- 1993/12/01 00:00
PHST- 1993/12/01 00:00 [pubmed]
PHST- 1993/12/01 00:01 [medline]
PHST- 1993/12/01 00:00 [entrez]
PST - ppublish
SO  - Rinsho Shinkeigaku. 1993 Dec;33(12):1265-9.