PMID- 8176632
OWN - NLM
STAT- MEDLINE
DCOM- 19940607
LR  - 20131121
IS  - 0914-5087 (Print)
IS  - 0914-5087 (Linking)
VI  - 23
IP  - 2
DP  - 1993
TI  - [Serum thyroid hormone levels correlate with cardiac function and ventricular 
      tachyarrhythmia in patients with chronic heart failure].
PG  - 205-13
AB  - The relationship between cardiac function and serum thyroid hormone levels was 
      investigated in 41 patients with chronic heart failure (25 men and 16 women, mean 
      age 63.7 +/- 11.1 years) and 15 normal subjects (5 men and 10 women, mean age 
      55.5 +/- 12.2 years). Patients with apparent thyroid disease were excluded from 
      the study. All patients were evaluated according to the New York Heart 
      Association (NYHA) classification using echocardiography, cardiothoracic ratios, 
      mean daily heart rates calculated from ambulatory electrocardiograms (ECG), and 
      ventricular tachyarrhythmias greater than triplets based on either Holter or ECG 
      monitoring. The serum free triiodothyronine (FT3), free thyroxine (FT4), and 
      reverse triiodothyronine (rT3) levels were measured. Decreased FT3 levels and 
      FT3/FT4 ratios, and increased rT3 levels were associated with worse NYHA class. 
      FT3/FT4 was positively and rT3 was negatively correlated with echocardiographical 
      fractional shortening. FT3 and rT3 were negatively and positively correlated with 
      mean daily heart rates, in contrast to known hypothyroid patients. Patients with 
      ventricular tachycardia demonstrated significantly lower serum values of FT3 and 
      FT3/FT4, and significantly higher values of rT3. Serum thyroid hormone levels can 
      provide a quantitative index for evaluating the severity of chronic heart failure 
      and predicting ventricular tachycardia.
FAU - Shimoyama, N
AU  - Shimoyama N
AD  - First Department of Internal Medicine, Medical College of Oita.
FAU - Maeda, T
AU  - Maeda T
FAU - Inoue, T
AU  - Inoue T
FAU - Niwa, H
AU  - Niwa H
FAU - Saikawa, T
AU  - Saikawa T
LA  - jpn
PT  - English Abstract
PT  - Journal Article
PL  - Netherlands
TA  - J Cardiol
JT  - Journal of cardiology
JID - 8804703
RN  - 0 (Thyroid Hormones)
RN  - 06LU7C9H1V (Triiodothyronine)
RN  - 5817-39-0 (Triiodothyronine, Reverse)
RN  - Q51BO43MG4 (Thyroxine)
SB  - IM
MH  - Echocardiography
MH  - Female
MH  - Heart/*physiology/physiopathology
MH  - Heart Failure/*blood/*physiopathology
MH  - Heart Rate
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Tachycardia, Ventricular/*blood/*physiopathology
MH  - Thyroid Hormones/*blood
MH  - Thyroxine/blood
MH  - Triiodothyronine/blood
MH  - Triiodothyronine, Reverse/blood
EDAT- 1993/01/01 00:00
MHDA- 1993/01/01 00:01
CRDT- 1993/01/01 00:00
PHST- 1993/01/01 00:00 [pubmed]
PHST- 1993/01/01 00:01 [medline]
PHST- 1993/01/01 00:00 [entrez]
PST - ppublish
SO  - J Cardiol. 1993;23(2):205-13.