PMID- 8176938
OWN - NLM
STAT- MEDLINE
DCOM- 19940608
LR  - 20190821
IS  - 0022-4790 (Print)
IS  - 0022-4790 (Linking)
VI  - 56
IP  - 1
DP  - 1994 May
TI  - Wilms' tumor: long-term results from a single institution.
PG  - 25-31
AB  - One-hundred-twelve children with pathological diagnosis of Wilms' tumor were 
      treated during the period 1979-1989. They were postoperatively staged as follows: 
      stage I, 25 patients; stage II, 27 patients; stage III, 48 patients; and stage 
      IV, 9 patients. Three patients were preoperatively classified as stage V. The 
      National Wilms' Tumor Study (NWTS) staging system was used. Except for Stage V 
      patients, the treatment regimen consisted of nephrectomy followed by radiotherapy 
      and/or chemotherapy according to stage of disease and pathology. Stage I, II, and 
      III patients with favorable histology enjoyed 94 +/- 6%, 86 +/- 8%, and 71 +/- 8% 
      10-year actuarial survival, respectively. Stage IV patients and those in stages 
      I, II, and III with unfavorable histology had a 10-year actuarial survival of 36 
      +/- 8%. Univariate analyses proved that NWTS stages affected the 10-year 
      actuarial disease-free survival rates but not the overall survival rates. The 
      histopathology significantly affected the disease-free survival and the overall 
      survival rates both in the whole group of patients and in each stage when 
      considered separately. The same histopathology also affected the incidence of 
      development of distant relapse but not the local recurrence rate. On the other 
      hand, massive tumor rupture at surgery increased the incidence of local relapse 
      but not of distant metastasis and did not affect the overall survival rates. The 
      presence of residuum after surgery had nearly the same effect as tumor rupture on 
      the local recurrence. It also did not increase significantly the distant relapse 
      incidence, but it affected significantly the overall survival. Retroperitoneal 
      lymph node involvement had a similar effect. It increased the incidence of local 
      relapse and decreased the 10-year overall survival rate but it had a borderline 
      effect on development of distant metastasis (P = 0.06). The age at diagnosis had 
      also a borderline effect on disease-free survival but it had not effect, of 
      statistical significance, on the overall survival.
FAU - Zaghloul, M S
AU  - Zaghloul MS
AD  - Radiotherapy Department, National Cancer Institute, Cairo, Egypt.
FAU - Hussein, M H
AU  - Hussein MH
FAU - el Koutbey, M
AU  - el Koutbey M
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Surg Oncol
JT  - Journal of surgical oncology
JID - 0222643
SB  - IM
MH  - Actuarial Analysis
MH  - Child
MH  - Child, Preschool
MH  - Combined Modality Therapy
MH  - Egypt
MH  - Humans
MH  - Infant
MH  - Kidney Neoplasms/pathology/*therapy
MH  - Lymphatic Metastasis
MH  - Neoplasm Recurrence, Local
MH  - Neoplasm Staging
MH  - Survival Analysis
MH  - Time Factors
MH  - Treatment Outcome
MH  - Wilms Tumor/pathology/secondary/*therapy
EDAT- 1994/05/01 00:00
MHDA- 1994/05/01 00:01
CRDT- 1994/05/01 00:00
PHST- 1994/05/01 00:00 [pubmed]
PHST- 1994/05/01 00:01 [medline]
PHST- 1994/05/01 00:00 [entrez]
AID - 10.1002/jso.2930560107 [doi]
PST - ppublish
SO  - J Surg Oncol. 1994 May;56(1):25-31. doi: 10.1002/jso.2930560107.