PMID- 8178175
OWN - NLM
STAT- MEDLINE
DCOM- 19940609
LR  - 20220310
IS  - 0036-8075 (Print)
IS  - 0036-8075 (Linking)
VI  - 264
IP  - 5162
DP  - 1994 May 20
TI  - Linkage analysis of IL4 and other chromosome 5q31.1 markers and total serum 
      immunoglobulin E concentrations.
PG  - 1152-6
AB  - Sib-pair analysis of 170 individuals from 11 Amish families revealed evidence for 
      linkage of five markers in chromosome 5q31.1 with a gene controlling total serum 
      immunoglobulin E (IgE) concentration. No linkage was found between these markers 
      and specific IgE antibody concentrations. Analysis of total IgE within a subset 
      of 128 IgE antibody-negative sib pairs confirmed evidence for linkage to 5q31.1, 
      especially to the interleukin-4 gene (IL4). A combination of segregation and 
      maximum likelihood analyses provided further evidence for this linkage. These 
      analyses suggest that IL4 or a nearby gene in 5q31.1 regulates IgE production in 
      a nonantigen-specific (noncognate) fashion.
FAU - Marsh, D G
AU  - Marsh DG
AD  - Johns Hopkins Asthma and Allergy Center, School of Medicine, Baltimore, MD 21224.
FAU - Neely, J D
AU  - Neely JD
FAU - Breazeale, D R
AU  - Breazeale DR
FAU - Ghosh, B
AU  - Ghosh B
FAU - Freidhoff, L R
AU  - Freidhoff LR
FAU - Ehrlich-Kautzky, E
AU  - Ehrlich-Kautzky E
FAU - Schou, C
AU  - Schou C
FAU - Krishnaswamy, G
AU  - Krishnaswamy G
FAU - Beaty, T H
AU  - Beaty TH
LA  - eng
GR  - 1 P41 RR03655/RR/NCRR NIH HHS/United States
GR  - AI20059/AI/NIAID NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Science
JT  - Science (New York, N.Y.)
JID - 0404511
RN  - 0 (Allergens)
RN  - 0 (Genetic Markers)
RN  - 207137-56-2 (Interleukin-4)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Allergens/immunology
MH  - Base Sequence
MH  - Child
MH  - Child, Preschool
MH  - *Chromosomes, Human, Pair 5
MH  - Female
MH  - Genes, MHC Class II
MH  - *Genetic Linkage
MH  - Genetic Markers
MH  - Humans
MH  - Hypersensitivity, Immediate/genetics
MH  - Immunoglobulin E/*blood
MH  - Interleukin-4/*genetics
MH  - Likelihood Functions
MH  - Lod Score
MH  - Male
MH  - Middle Aged
MH  - Molecular Sequence Data
EDAT- 1994/05/20 00:00
MHDA- 1994/05/20 00:01
CRDT- 1994/05/20 00:00
PHST- 1994/05/20 00:00 [pubmed]
PHST- 1994/05/20 00:01 [medline]
PHST- 1994/05/20 00:00 [entrez]
AID - 10.1126/science.8178175 [doi]
PST - ppublish
SO  - Science. 1994 May 20;264(5162):1152-6. doi: 10.1126/science.8178175.