PMID- 8178766
OWN - NLM
STAT- MEDLINE
DCOM- 19940609
LR  - 20190512
IS  - 0002-9173 (Print)
IS  - 0002-9173 (Linking)
VI  - 101
IP  - 5
DP  - 1994 May
TI  - A prospective study of cellular and immunologic changes in skin of allogeneic 
      bone marrow recipients. Relationship to clinical and histologic features of acute 
      graft-versus-host disease.
PG  - 597-602
AB  - The inflammation-associated molecules intercellular adhesion molecule (ICAM)-1, 
      endothelial lymphocyte adhesion molecule (ELAM)-1, vascular cell adhesion 
      molecule (VCAM)-1, human leukocyte antigen (HLA)-DR, interleukin (IL)-2R (CD25), 
      CD34, alpha-1-antichymotrypsin (alpha 1-ACT), and L1 antigen were studied in skin 
      from marrow recipients to determine the timing and distribution of their 
      expression in relation to the clinical and histologic evolution of 
      graft-versus-host disease (GvHD). Four phases were recognized: 1. pretransplant 
      with no immunohistologic change; 2. posttransplant with no evidence of GvHD when 
      dermal alpha 1-ACT + macrophages were increased; 3. posttransplant with clinical, 
      but not histologic, evidence of GvHD with increased keratinocyte HLA-DR and 
      ICAM-1 expression and increased numbers of VCAM-1+ dermal cells; and 4. 
      posttransplant with clinical and histologic evidence of GvHD characterized by an 
      infiltrate of CD25+ T cells, L1+, alpha 1-ACT+ and VCAM-1+ macrophages, L1 
      antigen expression on keratinocytes accompanied by further increases in HLA-DR 
      and ICAM-1, and increased endothelial ELAM-1 staining with a reciprocal decrease 
      in CD34. A sequential accumulation of cellular and molecular changes, therefore, 
      occurs in the evolution of acute GvHD, and immunostaining for HLA-DR, ICAM-1, and 
      VCAM-1 may be helpful in diagnosing early disease.
FAU - Norton, J
AU  - Norton J
AD  - Department of Histopathology, Royal Marsden Hospital, Sutton, Surrey, United 
      Kingdom.
FAU - Sloane, J P
AU  - Sloane JP
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Am J Clin Pathol
JT  - American journal of clinical pathology
JID - 0370470
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Bone Marrow Transplantation/*immunology/*pathology
MH  - Female
MH  - Graft vs Host Disease/*immunology/*pathology
MH  - Humans
MH  - Immunoenzyme Techniques
MH  - Male
MH  - Middle Aged
MH  - Prospective Studies
MH  - Skin/*immunology/*pathology
MH  - Transplantation, Homologous
EDAT- 1994/05/01 00:00
MHDA- 1994/05/01 00:01
CRDT- 1994/05/01 00:00
PHST- 1994/05/01 00:00 [pubmed]
PHST- 1994/05/01 00:01 [medline]
PHST- 1994/05/01 00:00 [entrez]
AID - 10.1093/ajcp/101.5.597 [doi]
PST - ppublish
SO  - Am J Clin Pathol. 1994 May;101(5):597-602. doi: 10.1093/ajcp/101.5.597.