PMID- 8180795
OWN - NLM
STAT- MEDLINE
DCOM- 19940616
LR  - 20190614
IS  - 0006-8993 (Print)
IS  - 0006-8993 (Linking)
VI  - 637
IP  - 1-2
DP  - 1994 Feb 21
TI  - Estrogen-progesterone and 8-OH-DPAT attenuate the lordosis-inhibiting effects of 
      the 5-HT1A agonist in the VMN.
PG  - 173-80
AB  - Ovariectomized rats were treated for 2 consecutive weeks with 25 micrograms 
      estradiol benzoate followed 48 h later with 500 micrograms progesterone. 
      Bilateral infusions of 200 ng 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT) 
      into the ventromedial nucleus of the hypothalamus (VMN) inhibited female sexual 
      behavior on the first but not the second week of hormone priming. Such 
      attenuation on the second week of priming did not appear to result from an 
      enhanced receptivity of the female rats since there were no differences in the 
      L/M ratios prior to drug infusion; nor was the attenuation a consequence of 
      infusion-induced VMN damage since neither saline nor 8-OH-DPAT preinfusions 
      prevented the later inhibitory effects of 8-OH-DPAT on lordosis behavior. 
      However, preinfusion with 8-OH-DPAT may have reduced the duration of the 
      inhibition. Hormone priming (without any VMN infusion) also partially attenuated 
      the effect of 8-OH-DPAT. Both hormone priming and treatment with 8-OH-DPAT were 
      required to eliminate the effects of the second 8-OH-DPAT treatment. Thus, the 
      present results suggest that gonadal hormones, alone, slightly attenuate the 
      effects of agonist activation of 5-HT1A receptors involved in the inhibition of 
      lordosis behavior; that agonist activation of 5-HT1A receptors also produces a 
      slight attenuation; but that both treatments together have a robust protective 
      action against the inhibitory effect of a 5-HT1A agonist on female lordosis 
      behavior.
FAU - Uphouse, L
AU  - Uphouse L
AD  - Department of Biology, Texas Woman's University, Denton 76204.
FAU - Caldarola-Pastuszka, M
AU  - Caldarola-Pastuszka M
FAU - Maswood, S
AU  - Maswood S
FAU - Andrade, M
AU  - Andrade M
FAU - Moore, N
AU  - Moore N
LA  - eng
GR  - GM08256/GM/NIGMS NIH HHS/United States
GR  - R01 HD28419/HD/NICHD NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - Netherlands
TA  - Brain Res
JT  - Brain research
JID - 0045503
RN  - 0 (Estrogens)
RN  - 0 (Serotonin Receptor Agonists)
RN  - 4G7DS2Q64Y (Progesterone)
RN  - 78950-78-4 (8-Hydroxy-2-(di-n-propylamino)tetralin)
SB  - IM
MH  - 8-Hydroxy-2-(di-n-propylamino)tetralin/administration & dosage/*pharmacology
MH  - Animals
MH  - Estrogens/administration & dosage/*pharmacology
MH  - Female
MH  - Injections
MH  - Ovariectomy
MH  - Posture/*physiology
MH  - Progesterone/administration & dosage/*pharmacology
MH  - Rats
MH  - Rats, Inbred F344
MH  - Serotonin Receptor Agonists/administration & dosage/*pharmacology
MH  - Sexual Behavior, Animal/*drug effects
MH  - Ventromedial Hypothalamic Nucleus/*physiology
EDAT- 1994/02/21 00:00
MHDA- 1994/02/21 00:01
CRDT- 1994/02/21 00:00
PHST- 1994/02/21 00:00 [pubmed]
PHST- 1994/02/21 00:01 [medline]
PHST- 1994/02/21 00:00 [entrez]
AID - 0006-8993(94)91230-0 [pii]
AID - 10.1016/0006-8993(94)91230-0 [doi]
PST - ppublish
SO  - Brain Res. 1994 Feb 21;637(1-2):173-80. doi: 10.1016/0006-8993(94)91230-0.