PMID- 8181807
OWN - NLM
STAT- MEDLINE
DCOM- 19940614
LR  - 20190821
IS  - 0309-0167 (Print)
IS  - 0309-0167 (Linking)
VI  - 24
IP  - 2
DP  - 1994 Feb
TI  - Immunohistochemical localization of transforming growth factor-beta 1 in the 
      lungs of patients with systemic sclerosis, cryptogenic fibrosing alveolitis and 
      other lung disorders.
PG  - 145-50
AB  - To study the role of transforming growth factor-beta 1 (TGF-beta 1) in the 
      pathogenesis of pulmonary fibrosis we have examined lung biopsies from nine 
      patients with systemic sclerosis and interstitial lung disease, eight with 'lone' 
      cryptogenic fibrosing alveolitis, two with cystic fibrosis, two with extrinsic 
      allergic alveolitis, two with Langerhans' cell histiocytosis, one with 
      lymphangioleiomyomatosis, one with giant cell interstitial pneumonia, and one 
      adenocarcinoma of the lung. In cryptogenic fibrosing alveolitis, both 'lone' and 
      associated with systemic sclerosis alveolar macrophages, bronchial epithelium and 
      hyperplastic type II pneumonocytes expressed intracellular TGF-beta 1. 
      Extracellular TGF-beta 1 was found in the fibrous tissue immediately beneath the 
      bronchial and hyperplastic alveolar epithelium. In normal lung, however, the 
      alveolar epithelium and alveolar interstitium were negative for both forms of 
      TGF-beta 1. There was strong expression of TGF-beta 1 in hyperplastic mesothelium 
      and its underlying connective tissue and in Langerhans' cells in the two cases of 
      histiocytosis. In the organizing pneumonia in cystic fibrosis, the intraalveolar 
      buds of granulation tissue reacted strongly for the extracellular form of 
      TGF-beta 1 and the overlying hyperplastic epithelium expressed the intracellular 
      form. In lymphangioleiomyomatosis, the aberrant smooth muscle cells strongly 
      expressed intracellular TGF-beta 1 and the extracellular form was expressed in 
      the adjacent connective tissue. In giant cell interstitial pneumonia, the 
      numerous alveolar macrophage including the multinucleate forms, expressed 
      intracellular TGF-beta 1, as did the hyperplastic alveolar epithelium.(ABSTRACT 
      TRUNCATED AT 250 WORDS)
FAU - Corrin, B
AU  - Corrin B
AD  - Department of Pathology, National Heart and Lung Institute, Royal Brompton 
      Hospital, London, UK.
FAU - Butcher, D
AU  - Butcher D
FAU - McAnulty, B J
AU  - McAnulty BJ
FAU - Dubois, R M
AU  - Dubois RM
FAU - Black, C M
AU  - Black CM
FAU - Laurent, G J
AU  - Laurent GJ
FAU - Harrison, N K
AU  - Harrison NK
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Histopathology
JT  - Histopathology
JID - 7704136
RN  - 0 (Transforming Growth Factor beta)
SB  - IM
MH  - Humans
MH  - Immunohistochemistry
MH  - Lung Diseases, Interstitial/immunology/*pathology
MH  - Pulmonary Fibrosis/immunology/*pathology
MH  - Scleroderma, Systemic/immunology/*pathology
MH  - Transforming Growth Factor beta/*analysis
EDAT- 1994/02/01 00:00
MHDA- 1994/02/01 00:01
CRDT- 1994/02/01 00:00
PHST- 1994/02/01 00:00 [pubmed]
PHST- 1994/02/01 00:01 [medline]
PHST- 1994/02/01 00:00 [entrez]
AID - 10.1111/j.1365-2559.1994.tb01293.x [doi]
PST - ppublish
SO  - Histopathology. 1994 Feb;24(2):145-50. doi: 10.1111/j.1365-2559.1994.tb01293.x.